Overview of the Harvard Catalyst Imaging program Randy

Overview of the Harvard Catalyst Imaging program Randy Gollub, MD, Ph. D; Valerie Humblet, Ph. D http: //catalyst. harvard. edu April 28, 2009

Institutions participating in Harvard CTSC Yearly budget: $38 million (23 NIH + 15 matching) Academic Healthcare Centers • Beth Israel-Deaconess Medical Center • Brigham and Women’s Hospital • Massachusetts General Hospital • Children’s Hospital Boston Specialty Hospitals and Institutes • Dana-Farber Cancer Institute • Forsyth Dental Institute • Joslin Diabetes Center • Massachusetts Eye and Ear Infirmary • Mc. Lean Hospital • Schepens Eye Research Institute Massachusetts Institutes of Technology Harvard University • Faculty of Arts and Sciences • Harvard Business School • Harvard School of Dental Medicine • Harvard Divinity School • Graduate School of Design • Graduate School of Education • Kennedy School of Government • Harvard Law School • Harvard Medical School • Harvard School of Public Health • Harvard School of Engineering Community Healthcare Institutions • Cambridge Health Alliance • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 1

Harvard Catalyst • Programs (Selected list) – – – – – Development of Novel C/T Methodologies Biomedical Informatics Research Education, Career Development Pilot studies Community Engagement Design and Biostatistics Diversity and Health Disparities Research Ethics Linkages across the institutions Regulatory Knowledge and Support 2

Imaging Consortium Team Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director Gordon J. Harris, Site Co-Director Annick D. Van den Abbeele, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison Yong Gao, XNAT Engineer 3

Mission of the Imaging Consortium • Expand imaging in clinical research – Build infrastructure (software, image analysis and visualization tools, cross-site acquisition tools) – Provide expert consultation in the use of imaging as part of clinical translational research – Educate and advise about available imaging and image processing capabilities in the Harvard environment. – Provide education at the local and national level (participation in RSNA education program) 4

Image Consortium Consultation Service 5

Technologies and Expertise • Cancer imaging, MRI, PET, CT, f. MRI, US, pediatric imaging, neuroimaging. • Focused on assisting with planning and design of research proposals and/or methods for image analysis. • Consultation is available for the preparation of a grant or IRB submission. • We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 6

Examples of Imaging Consultation • Standardization of physiologic monitoring system for MRI. – Deployed at 6 institutions (MGH, BWH. BIDMC, CHB, MIT, Harvard) – Creation of a biomedical engineer working group 7

Examples of Imaging Consultation • Development of lingual nerve imaging (MGHBIDMC) – MGH maxillofacial surgeon contacted us regarding pre-op imaging of lingual nerve – Bob Lenkinski (BIDMC) had expertise in MRI nerve imaging – Healthy volunteer was scanned at BIDMC – Head and neck radiologist (BIDMC) will help with reading of images 8

Examples of Imaging Consultation • Study of brain-development in premature infants (new collaboration: CHB-BWH-MGH) CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR) Optical Imaging of Cerebral Oxygenation in Infants (MGH) 9

Medical Imaging Informatics • Examples: – Clinical: • Ruling out appendicitis based on CT scans. Are there metrics that can be found by analyzing clinical data? • Quantitative output from Freesurfer for Alzheimer disease – Research: • Helping TIMC get easier access to PACS system for clinical trials 10

Medical Imaging Informatics • IT Catalyst infrastructure: – i 2 b 2: scalable computational framework to help translation of genomic findings. – BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. – NA-MIC: robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer. 11

Medical Imaging Informatics Dr X Desktop Pediatric rare disease PACS Dr Z Desktop Chronic pain management Dr Y Desktop Alzheimer XNAT Enterprise Annotating Genomic Data #2 Project Management Natural Language Processing Identity Management Data Repository (CRC) Annotating Genomic Data #1 PACS De Identification Of data File Repository Ontology Management Dr W Desktop Quantitative cancer biomarkers Workflow Framework Correlation Analysis i 2 b 2 HIVE 12

Educational Program • Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff • Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc) • Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms • Dissemination: through national networks (CTSA, RSNA, IRAT, SNM) 13

Pilot funds • Eligibility: All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. • First round: 62 projects funded (out of 602) • Funds: Pilot Grants will be awarded in the amount of $50, 000, with an award period of one year. (80 grants expected) • Deadlines: Letter of intent: May 13, 2009 Full application: June 12, 2009 • Contact: Harvard Catalyst Research Navigators 617 432 -7800 14

http: //catalyst. harvard. edu Image_Consult@catalyst. harvard. edu www. na-mic. org/Wiki/index. php/Collaboration: Harvard_CTSC 15