Overview of the Harvard Catalyst Imaging program how

Overview of the Harvard Catalyst Imaging program- how to use the resources for your research Randy Gollub, MD, Ph. D http: //catalyst. harvard. edu May 19, 2009

Harvard Catalyst: The History and the Basics • GCRC program (20+ yr NCRR/NIH funded clinical research support program) discontinued – MGH Biomedical Imaging Core established 2002 • CTSA 2007(Roadmap initiative) • HU- Response-Harvard Catalyst – (PI Lee Nadler/Co-Director: Steve Freedman) • We are a pan-Harvard enterprise dedicated to improving human health by: – Creating Connections – Enabling research At the Cutting Edge of discovery – Nurturing clinical and translational researchers 1

Imaging Consortium History • MGH and BWH GCRC Imaging Cores NCRR – MGH and BWH P 41 s devoted to medical imaging • Martinos Center for Functional Imaging Technologies (Rosen) • Neuroimage Analysis Center (Kikinis) • Image Guided Therapy (Jolesz) – Biomedical Informatics Research Network (BIRN) • Morphometry Testbed (Rosen) • Functional Neuroimaging Testbed NIH NCBC – National Alliance for Medical Image Computing (NA-MIC) Fee for Service (MGH/BWH/DFCC) – DFCI Tumor Metrics Core

Institutions participating in Harvard CTSC Yearly budget: $38 million (23 NIH + 15 matching) Academic Healthcare Centers • Beth Israel-Deaconess Medical Center • Brigham and Women’s Hospital • Massachusetts General Hospital • Children’s Hospital Boston Specialty Hospitals and Institutes • Dana-Farber Cancer Institute • Forsyth Dental Institute • Joslin Diabetes Center • Massachusetts Eye and Ear Infirmary • Mc. Lean Hospital • Schepens Eye Research Institute Massachusetts Institutes of Technology Blue –Imaging Consortium Harvard University • Faculty of Arts and Sciences • Harvard Business School • Harvard School of Dental Medicine • Harvard Divinity School • Graduate School of Design • Graduate School of Education • Kennedy School of Government • Harvard Law School • Harvard Medical School • Harvard School of Public Health • Harvard School of Engineering Community Healthcare Institutions • Cambridge Health Alliance • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 3

Harvard Catalyst • Programs (Selected list) – – – Translational Technologies (Imaging & Genetics) Participant and Clinical Interactions Resource (PCIR) Development of Novel C/T Methodologies Biomedical Informatics Pilot studies Design and Biostatistics (Mark Vangel) Research Education, Career Development Diversity and Health Disparities Research Ethics Linkages across the institutions Regulatory Knowledge and Support 4

Imaging Consortium Team Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director Gordon J. Harris, Site Co-Director Annick D. Van den Abbeele, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison Yong Gao, Imaging Informatics Architect 5

Mission of the Imaging Consortium • Expand imaging in clinical research: – Build & deploy infrastructure (expertise in single and cross site image acquisition, image analysis, visualization & data management software tools) – Provide expert consultation in the use of imaging for clinical translational research – Educate and advise about available imaging and image processing capabilities in the Harvard environment – Provide leadership & education at the local and national level 6

Harvard Catalyst website http: //catalyst. harvard. edu/home. html 7

Image Consortium Consultation Service 8

Image Consortium Consultation Service 9

Technologies and Expertise • Cancer imaging, MRI, PET, CT, f. MRI, US, pediatric imaging, neuroimaging. • Focused on assisting with planning and design of research proposals and/or methods for image analysis. • Consultation is available for the preparation of a grant or IRB submission. • We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 10

Example of Imaging Consultation • Study of brain-development in premature infants (new collaboration: CHB-BWH-MGH) CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR) Optical Imaging of Cerebral Oxygenation in Infants (MGH) 11

Pilot funds • Eligibility: All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. • First round: 62 projects funded (out of 602) • Funds: Pilot Grants will be awarded in the amount of $50, 000, with an award period of one year. (80 grants expected) • Deadlines: Letter of intent: May 13, 2009 Full application: June 12, 2009 • Contact: Harvard Catalyst Research Navigators 617 432 -7800 12

MGH Biomedical Imaging Core 13

MGH Biomedical Imaging Core http: //www 2. massgeneral. org/crc/bic/index. htm 14

MGH Biomedical Imaging Core http: //www 2. massgeneral. org/crc/bic/index. htm 15

MGH Biomedical Imaging Core http: //www 2. massgeneral. org/crc/bic/index. htm 16

MGH Biomedical Imaging Core TMS 17

MGH Biomedical Imaging Core http: //www 2. massgeneral. org/crc/bic/index. htm 18

MGH BIC Imaging Engineers Deployed cross site calibrated physiologic monitoring systems for MRI at BWH, Children’s, BIDMC, Harvard FAS and MIT Catalyst created a community of biomedical engineers w/ a shared focus on supporting C/T imaging 19

MGH Biomedical Imaging Core http: //www 2. massgeneral. org/crc/bic/index. htm 20

MGH Biomedical Imaging Core http: //www 2. massgeneral. org/crc/bic/index. htm 21

MGH Biomedical Imaging Core 22

MGH Biomedical Imaging Core Coming in July 2009! Webform PCIR application 23

Medical Imaging Informatics • Examples: – Clinical: • Ruling out appendicitis based on CT scans. Are there metrics that can be found by analyzing clinical data? • Quantitative output from Freesurfer for Alzheimer disease – Research: • Helping TIMC get easier access to PACS system for clinical trials 24

Medical Imaging Informatics Secondary Use of Clinical Imaging Data (Integration with i 2 b 2) Desikan et al, Brain in press Standard T 1 MRI scan AUC 0. 95 (specificity 91%, sensitivity 90% to discriminate MCI from age matched controls 25

Medical Imaging Informatics • IT Catalyst infrastructure: – i 2 b 2: scalable computational framework to help translation of genomic findings. – BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. – NA-MIC: robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer. 26

Medical Imaging Informatics Dr X Desktop Pediatric rare disease PACS Dr Z Desktop Chronic pain management Dr Y Desktop Alzheimer XNAT Enterprise Annotating Genomic Data #2 Project Management Natural Language Processing Identity Management Data Repository (CRC) Annotating Genomic Data #1 PACS De Identification Of data File Repository Ontology Management Dr W Desktop Quantitative cancer biomarkers Workflow Framework Correlation Analysis i 2 b 2 HIVE 27

Educational Program • Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff • Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc) • Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms • Dissemination: through national networks (CTSA, RSNA, IRAT, SNM) 28

National Effort in C/T Research 39 AHC/23 states Mayo Clinic Northwestern UC Davis Cornell J. Hopkins Duke Emory U. Wash. U. Source: http: //www. ctsaweb. org/ • Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08 • 14 Imaging programs-(Dan Sullivan/RSNA) 29

http: //catalyst. harvard. edu Image_Consult@catalyst. harvard. edu www. na-mic. org/Wiki/index. php/Collaboration: Harvard_CTSC 30