Overview of the Harvard Catalyst Imaging program Clare

Overview of the Harvard Catalyst Imaging program Clare. Tempany, MD; Ron Kikinis, MD; Valerie Humblet, Ph. D http: //catalyst. harvard. edu April 9, 2009

Agenda • • Harvard Catalyst Imaging Consortium Technology and Expertise IT Structure Why be a consultant ? Educational Opportunities Contact 1

Harvard Catalyst: The History and the Basics • GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued – BWH/MGH imaging cores (CT/AVD/GS) • CTSA 2007(Roadmap initiative-EAZ) • HU- Response-Harvard Catalyst – (PI Lee Nadler/Co-Director: Steve Freedman) – GCRC replaced by PCIR • We are a pan-Harvard enterprise dedicated to improving human health by: – Creating Connections – Enabling research At the Cutting Edge of discovery – Nurturing clinical and translational researchers 2

National Effort in C/T Research 38 AHC/23 states Mayo Clinic Northwestern UC Davis Cornell J. Hopkins Duke Emory U. Wash. U. Source: http: //www. ctsaweb. org/ • Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08 • Imaging programs-(Dan Sullivan/RSNA) 3

Institutions participating in Year 01 total budget: $22, 148, 106 Harvard CTSC Academic Healthcare Centers • Beth Israel-Deaconess Medical Center • Brigham and Women’s Hospital • Massachusetts General Hospital • Children’s Hospital Boston Specialty Hospitals and Institutes • Dana-Farber Cancer Institute • Forsyth Dental Institute • Joslin Diabetes Center • Massachusetts Eye and Ear Infirmary • Mc. Lean Hospital • Schepens Eye Research Institute Massachusetts Institutes of Technology Red –Imaging Consortium Harvard University • Faculty of Arts and Sciences • Harvard Business School • Harvard School of Dental Medicine • Harvard Divinity School • Graduate School of Design • Graduate School of Education • Kennedy School of Government • Harvard Law School • Harvard Medical School • Harvard School of Public Health • Harvard School of Engineering Community Healthcare Institutions • Cambridge Health Alliance • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 4

Harvard catalyst • Programs (Selected list) – – – – – Biomedical Informatics-Kohane Community engagement Design and Biostats Dev of Novel CT methodologies-Vikas Diversity/Health Disparities research Ethics Linkages-HL, HBS, Kennedy School etc Pilot studies Regulatory-BB Research Education 5

Harvard catalyst • Programs – Translational Technologies and Resources (TTR)-Gordon Williams (Imaging) – increases investigator awareness and utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies. 6

Pilot funds • Eligibility: All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. • Funds: Pilot Grants will be awarded in the amount of $50, 000, with an award period of one year. • Deadlines: Letter of intent: May 13, 2009 Full application: June 12, 2009 • Contact: Harvard Catalyst Research Navigators 617 432 -7800 7

Imaging Consortium Team Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director Gordon J. Harris, Site Co-Director Annick D. Van den Abbeele, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison Yong Gao, XNAT Engineer 8

Mission of the Imaging Consortium • Expand imaging in clincial research – To build infrastructure • Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research • IT framework • Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging, techniques, capabilities and image processing capabilities in the Harvard environment. 9

Harvard Catalyst website • Access to resources and profiles http: //catalyst. harvard. edu/home. html 10

Image Consortium Consultation Service • Access to the consultation service: http: //catalyst. harvard. edu/home. html 11

Technologies and Expertise • Cancer imaging, MRI, PET, CT, f. MRI, pediatric imaging, neuroimaging. • Focused on assisting with planning and design of research proposals and/or methods for image analysis. • Consultation is available for the preparation of a grant or IRB submission. • We do not provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 12

Imaging Consultation Service • Investigator fill webform on Catalyst website – Name, institution, nature research, reason for consult • Medical Imaging Liaison – dispatches request to the imaging consortium – Follow-up with investigator • Consultations discussed weekly • Designated consultant contacts investigator 13

Becoming an Imaging Consultant • Potential benefits of being an active collaborator: – – Good framework for research Research opportunities through collaborations Meeting experts out of radiology Networking with imaging cores outside of Boston • Examples: – Standardization of physiologic monitoring system for f. MRI – Development lingual nerve imaging (MGH-BIDMC) – Study of brain-development in premature infants (CHBBWH-MGH) – Liver inflammation – Cardiac conductivity study 14

Educational Opportunities proposal • Nanocourse: – Imaging 101 to increase knowledge about imaging • More advanced classes for radiologists: – Tumor metrics – Radiation safety issues for IRB submission – Hands-on classes on data analysis – Imaging perfusion – Example: www. na-mic. org/Wiki/images/8/8 b/Slicer 3 Training_Change. Tracker. ppt 15

XNAT-PACS-i 2 b 2 Integration • IT Catalyst infrastructure: – i 2 b 2: scalable computational framework to help translation of genomic findings. – BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. – NA-MIC: robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: slicer. Freesurfer. 16

XNAT-PACS-i 2 b 2 Integration Dr X Desktop Pediatric rare disease PACS Dr Z Desktop Chronic pain management Dr Y Desktop Alzheimer XNAT Enterprise Annotating Genomic Data #2 Project Management Natural Language Processing Identity Management Data Repository (CRC) Annotating Genomic Data #1 PACS De Identification Of data File Repository Ontology Management Dr W Desktop Quantitative cancer biomarkers Workflow Framework Correlation Analysis i 2 b 2 HIVE Slicer: Data visualization analysis 17

Invitation • Please consider getting involved – Info- Google Harvard catalyst – Pls sign up as a potential consultant today! – Pilot grants (est x 2 application dates per year) – Watch your email- attend meetings symposiums to meet new research colleagues 18

http: //catalyst. harvard. edu Image_Consult@catalyst. harvard. edu www. na-mic. org/Wiki/index. php/Collaboration: Harvard_CTSC 19