Osler Institute Pathology Board Review Electron Microscopy EM

Osler Institute – Pathology Board Review: Electron Microscopy EM of Tumors and Tumor-like Entities

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Oncocytoma • Salivary gland • Parotid • Kidney

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Oncocytoma • Pleomorphic mitochondria • Lamelliform (plate like) mitochondrial cristae • Dense bodies in mitochondria

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Plasmacytoma • Nuclei Marginated heterochromatin • Prominent profiles of rough endoplasmic reticulum • Immunoglobulin inclusions in RER and nucleus

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Renal Cell Carcinoma (conventional type) • • • Long microvilli Glycogen Lipid droplets

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Renal Cell Carcinoma Chromophobe Type • Microvesicles • Hale’s colloidal iron positive Papillary (chromophil) Type • Abundant mitochondria

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Seminoma • Wandering, ropy, nucleolus • Finely dispersed heterochromatin • Inconspicuous organelles • Intercellular junctions

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Squamous cell carcinoma • Desmosomes • Tonofilament bundles

Electron Microscopy - Osler Institute Pathology Board Review Small Round Cell Tumors

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Ewings Sarcoma • Dispersed heterochromatin • Small nucleolus

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Ewings Sarcoma • Large pools of glycogen

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Rhabdomyosarcoma • Actin-myosin filaments with Zband • Primitive sarcomeres

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Rhabdomyosarcoma • Ribosome-filament complexes • Small primitive junctions • External lamina

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Neuroblastoma • • Cell processes Secretory granules Microtubules Neurofilaments

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Lymphoma (Follicular Center Cell) • No cell junctions