Organic Compounds Compounds that contain CARBON are called
Organic Compounds • Compounds that contain CARBON are called organic • Macromolecules are large organic molecules
Carbon (C) • Carbon has 4 electrons in outer shell. • Carbon can form covalent bonds with as many as 4 other atoms (elements). • Usually with: • C, H, O or N. N 2
Macromolecules • Large organic molecules. • Also called POLYMERS • Made up of smaller • “building blocks”: • MONOMERS 3
Four Major Types of Biological Macromolecules Type of Polymer Monomers making up Polymer Example I. Carbohydrates (Polysaccharides) Monosaccharides Sugars, Starch, Cellulose II. Lipids (not true polymers) Fats, steroids, cholesterol III. Proteins Amino acids Enzymes, structural components IV. Nucleic Acids Nucleotides DNA, RNA
I. Carbohydrates • Made from monomers called monosaccharides (simple sugars) – Short term energy – Glucose: most common, used directly in cellular respiration to make ATP (energy)
Figure 5. 3 The structure and classification of some monosaccharides
Disaccharides
Polysaccharides: Complex Carbohydrates • 3 major types made from monomers of glucose: – Starch: energy storage in plants – Glycogen: energy storage in animals – Cellulose: structural molecules in plants
Figure 5. 6 Storage polysaccharides
Figure 5. 7 a Starch and cellulose structures
Figure 5. 7 b, c Starch and cellulose structures
Figure 5. 8 The arrangement of cellulose in plant cell walls
II. Lipids • Not true polymers • Composed of mostly glycerol and fatty acids • Includes – Fats: energy storage – Phospholipids: membranes – Steroids: hormones, cholesterol
Fats are made of one glycerol and three fatty acids
Double bonds between carbons cause kinks in hydrocarbons. H 2 C CH 2 H 2 C CH Kink CH H 2 C CH 2 Unsaturated fatty acid Double bonds, fewer H atoms Saturated fatty acid No Double bonds, maximum H atoms
Figure 5. 11 Examples of saturated and unsaturated fats and fatty acids
Phospholipids are made of one phosphate group and 2 fatty acids Phospholipids are amphipathic
Figure 5. 13 Two structures formed by self-assembly of phospholipids in aqueous environments
Steroids consist of a complex carbon ring structure Figure 5. 14 Cholesterol, a steroid
Figure 4. 8 A comparison of functional groups of female (estradiol) and male (testosterone) sex hormones
III. Proteins • Made from monomers called amino acids • Very different structures, very different functions H Amino group H 2 N C R Side chain O C OH Carboxyl group
The R groups of an amino acid may be hydrophobic or hydrophilic
Amino acids are joined together by a dehydration reaction H H 2 N C H Carboxyl group O C OH Amino group + H H H 2 O H N C CH 3 O C OH H O H 2 N C C H H O N C C H Peptide bond CH 3 OH
Many amino acids joined together = Polypeptide chain N-terminus H C-terminus H H O H H O N C C C C N C C C H C CH 3 N N C CH 2 OH C OH O CH 2 CH H 3 C CH 3 C CH 2 SH OH OH
The sequence of amino acids in the polypeptide chain = the primary structure of a protein
Hydrogen bonds between amino acids leads to the secondary structure of a protein Two common secondary structures are the -helix and pleated sheet
Further folding of the polypeptide chain contributes to the tertiary structure of a protein
The joining of more than one polypeptide chain leads to the quaternary structure of proteins
Heat (energy) can break up the structure of a protein
Table 5. 1 An Overview of Protein Functions
IV. Nucleic Acids • Nucleic acids (DNA and RNA) are made of monomers called nucleotides Nitrogenous base Phosphate group Sugar
Figure 5. 29 The components of nucleic acids
Figure 3. 17 b 3´ 5´ DNA is a double helix. 5´ 5´ 3´ T T A G C C G T A A C G G C A T T A C G C T A T G C T A Cartoon of base pairing 5´ 3´ A G C C G T T C G G A T A A T G C A 3´ G 5´ T Cartoon of double helix 3´ 5´ 3´ Space-filling model of double helix
Nucleic acids store the information to make proteins
Figure 5. 30 The DNA double helix and its replication
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