Optimal interleukin7 receptormediated signaling cell cycle progression and

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Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity by Alice Melão, Maureen Spit, Bruno A. Cardoso, and João T. Barata haematol Volume 101(11): 1368 -1379 October 31, 2016 © 2016 by Ferrata Storti Foundation

Immunophenotypic characteristics, maturation stage and IL 7 R mutational status of T-ALL primary cells

Immunophenotypic characteristics, maturation stage and IL 7 R mutational status of T-ALL primary cells and cell lines. Alice Melão et al. Haematologica 2016; 101: 1368 -1379 © 2016 by Ferrata Storti Foundation

CK 2 activity modulates IL-7 -mediated signaling in T-ALL cells. Alice Melão et al.

CK 2 activity modulates IL-7 -mediated signaling in T-ALL cells. Alice Melão et al. Haematologica 2016; 101: 1368 -1379 © 2016 by Ferrata Storti Foundation

CK 2 activity is required for IL-7 -mediated Bcl-2 upregulation, mitochondrial homeostasis and prevention

CK 2 activity is required for IL-7 -mediated Bcl-2 upregulation, mitochondrial homeostasis and prevention of T-ALL cell apoptosis. Alice Melão et al. Haematologica 2016; 101: 1368 -1379 © 2016 by Ferrata Storti Foundation

CK 2 activity is essential for IL-7 -mediated T-ALL cell growth and cell cycle

CK 2 activity is essential for IL-7 -mediated T-ALL cell growth and cell cycle progression. Alice Melão et al. Haematologica 2016; 101: 1368 -1379 © 2016 by Ferrata Storti Foundation

CK 2 inhibition abolishes IL-7 -mediated viability, activation and proliferation of primary T-ALL blasts

CK 2 inhibition abolishes IL-7 -mediated viability, activation and proliferation of primary T-ALL blasts from diagnostic pediatric patients. Alice Melão et al. Haematologica 2016; 101: 1368 -1379 © 2016 by Ferrata Storti Foundation

CK 2 inhibition abolishes constitutive IL-7 R-mediated signaling and survival of T-ALL cells expressing

CK 2 inhibition abolishes constitutive IL-7 R-mediated signaling and survival of T-ALL cells expressing mutant IL-7 Rα. Alice Melão et al. Haematologica 2016; 101: 1368 -1379 © 2016 by Ferrata Storti Foundation

CK 2 and JAK inhibitors synergize in inducing cell death of IL-7 R mutant-expressing

CK 2 and JAK inhibitors synergize in inducing cell death of IL-7 R mutant-expressing and IL-7 stimulated T-ALL cells. Alice Melão et al. Haematologica 2016; 101: 1368 -1379 © 2016 by Ferrata Storti Foundation

Model for CK 2 involvement in IL-7/IL-7 R-mediated signaling in T-ALL. Alice Melão et

Model for CK 2 involvement in IL-7/IL-7 R-mediated signaling in T-ALL. Alice Melão et al. Haematologica 2016; 101: 1368 -1379 © 2016 by Ferrata Storti Foundation