Optical Imaging of Intrinsic Cortical Signals Group 24

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Optical Imaging of Intrinsic Cortical Signals Group #24 Shivani Shah, Ania Warczyk, Alia Durrani,

Optical Imaging of Intrinsic Cortical Signals Group #24 Shivani Shah, Ania Warczyk, Alia Durrani, Daniel Maxwell, Timothy Chen

Past Project n Abandoned previous project: “Laparoscopic Smart Instruments for Detecting Nerve Bundles and

Past Project n Abandoned previous project: “Laparoscopic Smart Instruments for Detecting Nerve Bundles and Vasculature During Prostatectomy” n Communication breakdown (mentor located at NIH in Bethesda, MD) n Lack of resources, knowledge n Found previous device design similar to goal of project (Cather. Map Surgical Aid) n

New Project n Design an implantable camera for optical imaging of the visual cortex

New Project n Design an implantable camera for optical imaging of the visual cortex area of the brain (awake imaging) n Further understand physiology of the brain Work with Psychological Sciences Department at Vanderbilt University n New Mentor: Dr. Anna Roe, Ph. D. n

Question/Thesis n Problem Statement n Design an implantable camera for optical imaging of the

Question/Thesis n Problem Statement n Design an implantable camera for optical imaging of the visual cortex n n n Performance Criteria n n Without requiring subject immobilization Being tested on laboratory rats and monkeys Head-worn camera Primary Objective n n Measuring hemodynamic signals related to neural activity Could be implanted or detachable

Background and Importance n Solution Description n Build upon previous work by summer intern

Background and Importance n Solution Description n Build upon previous work by summer intern n Clover CCM 625 Miniature Security Camera

Rat Cortex Imaging: 7/15/2004 Image Courtesy Vanderbilt Psychology Department

Rat Cortex Imaging: 7/15/2004 Image Courtesy Vanderbilt Psychology Department

Methods n Goals n n n Thorough patent search within next two weeks Constant

Methods n Goals n n n Thorough patent search within next two weeks Constant communication with advisor Factors n n Future human applications – working with neurosurgeons Design camera including: n n CCD Chip LED illuminators Battery for power Possible wireless transmission for data

Status/Results Currently in Research and Design phase n Conducting Digital Camera patent searches n

Status/Results Currently in Research and Design phase n Conducting Digital Camera patent searches n Communicate with Vanderbilt Electrical Engineering faculty members n Attempting to work with past prototype n Implement new technology n Investigate wireless feasibility n

Conclusions Current project has clinical significance for potential human applications n Further investigate physiology

Conclusions Current project has clinical significance for potential human applications n Further investigate physiology of visual cortex n Reduce physical stress on animal subjects n