Opportunities for Biomedical Computing and Informatics Research Funding

Opportunities for Biomedical Computing and Informatics Research Funding at NIH Zohara Cohen, Ph. D Program Director NIBIB, NIH, DHHS KOrean Computer Scientists and Engineers Association in America (KOCSEA) Technical Symposium October 26, 2008

NIH Mission and Structure NIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

NIH Structure OD NIAAA NIAID NIAMS NIBIB NICHD NIDCR NIDDK NIDA NIEHS NIGMS NIMH NINDS NINR NCI NEI NCCAM NCMHD NCRR NHGRI NHLBI NLM FIC CC CSR CIT National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

NIBIB Mission The mission of the National Institute of Biomedical Imaging and Bioengineering is to improve health by leading the development and accelerating the application of biomedical technologies. NIBIB is committed to integrating the physical and engineering sciences with the life sciences to advance basic research and medical care. National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

www. nibib. nih. gov National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Current NIBIB Portfolio Areas • • • Biomaterials Biomedical Informatics Biosensors Drug & Gene Delivery Systems Image-Guided Interventions Image Processing and Display Magnetic Resonance Imaging and Spectroscopy Mathematical Modeling, Simulation, and Analysis Medical Devices and Implant Science Micro-Biomechanics Micro- and Nano-Systems; Platform Technologies • • • Molecular Imaging Nanotechnology Nuclear Medicine Optical Imaging and Spectroscopy Rehabilitation Engineering Sensors Surgical Tools, Techniques, and Systems Telehealth Tissue Engineering Ultrasound: Diagnostic and Interventional X-ray, Electron, and Ion Beam National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Biomedical Information Science and Technology Initiative (BISTI) • established in May 2000 to serve as the focus of biomedical computing issues at the NIH • a consortium of representatives from each of the NIH institutes and centers • mission: – make optimal use of computer science and technology to address problems in biology and medicine – foster new basic understandings, collaborations, and transdisciplinary initiatives between the computational and biomedical sciences • coordinates research grants, training opportunities, and scientific symposia associated with biomedical computing http: //bisti. nih. gov/

BISTI FOA’s • Innovations in Biomedical Computational Science and Technology (R 01) - PAR-07 -344 • Exploratory Innovations in Biomedical Computational Science and Technology (R 21) - PAR-06 -411 • Innovations in Biomedical Computational Science and Technology Initiative (SBIR [R 43/R 44]) - PAR-07 -160 • Innovations in Biomedical Computational Science and Technology Initiative (STTR [R 41/R 42]) - PAR-07 -161 • Continued Development and Maintenance of Software (R 01) - PAR-08 -010 http: //bisti. nih. gov/ National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

National Centers for Biomedical Computing (NCBCs) • BISTI • Roadmap NCBC’s • Blueprint for Neuroscience • IMAG • CTSA Informatics Coordinating Committee • Nano. Health Enterprise • Physio. Net Resource • Osteoarthritis Initiative • ca. BIG Imaging Informatics Workspace www. ncbcs. org National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

NCBC-Related FOA’s • Collaborations with National Centers for Biomedical Computing (R 01) - PAR-07 -249 • Exploratory Collaborations with National Centers for Biomedical Computing (R 21) - PAR-07 -250 National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Interagency Modeling and Analysis Group

Multiscale Modeling • spans scales from molecular to population • encompasses concepts of space, time and state space • expected to impact the understanding of biological processes • further the predictive capability in biomedical systems Genes m. RNA Proteins Lipids Carbohydrates Cell structure -function Tissue Organ structure -function 200+ cell types 4 tissue types 12 organ systems Clinical medicine … 30, 000+ genes 100, 000+ proteins 1 body Courtesy of Peter Hunter

www. nibib. nih. gov/Research/Multi. Scale. Modeling National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

IMAG Wiki http: //www. imagwiki. org/mediawiki 10 Working Groups National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

IMAG Multiscale Modeling (MSM) Consortium Working Groups • • • WG 1 - Filament Dynamics and Simulation (FDS) WG 2 - Cardiac and Skeletal Muscle Physiology WG 3 - Macro-To-Micro Scale Imaging and Transport in Human Systems WG 4 - Cell Level Modeling WG 5 - High Performance Computing, Computational Issues and Algorithms WG 6 - Tissue Mechanics WG 7 - Multiscale Imaging WG 8 – Theoretical Methods WG 9 – Nano-modeling WG 10 – Model Sharing

Multiscale Modeling of the Physiome and the NIH vision for the 21 st Century Grace C. Y. Peng, Ph. D April 10 -11, 2008 International Physiome Symposium 2008 Toward Holistic Medicine: Physiome and Oriental Medicine Seoul, Korea

Please Populate Korea Page Promoting Global Cooperation and Awareness http: //www. imagwiki. org/mediawiki National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

IMAG-Related FOA 12 NIH participating institutes 3 years, 9 receipt dates

PAR 08 -023 Objectives • To develop multiscale models that link at least two biological scales of modeling and accurately predict biomedical and behavioral processes in health and disease states • To develop predictive, multiscale models that link to higher levels of the physiome. Models must link to at least one scale beyond molecular interactions at the cellular level (e. g. to cell-cell, cellenvironment interactions, as listed above) • To develop predictive, multiscale models that are physiologically mechanistic and have translational potential or clinical applicability • To bring together modeling and biomedical expertise to collaborate on building multiscale model(s) • To validate and test models with standard datasets • To develop models that can be explicitly shared with other modelers

NIH Blueprint for Neuroscience Research National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Neuroimaging Tools and Resources Clearinghouse (NITRC) Goal: Provide an independent clearinghouse for neuroimaging tools, vocabularies and datasets that promotes adoption and evolution of these resources by providing access, advice, and forums for input and discussion for both developers and the widespread user community. National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

www. nitrc. org National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

NITRC-Related FOAs NIH Blueprint provides supplemental funding to support enhancement of existing neuroimaging informatics tools and resources to improve interoperability, adoptability, dissemination, and usability. • Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination (R 03) – PAR -07 -417 • Notice of Availability of Administrative Supplements for Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination - NOT-EB-08 -002 National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

BIRN: Biomedical Informatics Research Network • dfsdfasdf National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

BIRN and ca. BIG-Related FOA’s • Sharing Data and Tools: Federation using the BIRN and ca. BIG Infrastructures (R 01) – PAR-07 -426 • Data Ontologies for Biomedical Research (R 01) – PAR-07 -425 National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Biotechnology Resource Centers: a NCRR and NIBIB Program

Other Active NIH FOA’s with Relevance to Biomedical Computing and Informatics • Bioengineering Research Partnerships (R 01) - PAR-07 -352 • Bioengineering Research Grants (R 01) - PA-07 -279 • NLM Express Research Grants in Biomedical Informatics (R 01) - PAR-08 -080 http: //grants. nih. gov/grants/guide/ National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Thank You! Zohara Cohen zcohen@mail. nih. gov National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

The Future Paradigm: The 4 P’s Transform Medicine from Curative to Preemptive Predictive Personalized Participatory Preemptive