OPA15406 a novel topical nonsteroidal selective phosphodiesterase4 PDE Slides: 6 Download presentation OPA-15406, a novel, topical, nonsteroidal, selective phosphodiesterase-4 (PDE 4) inhibitor, in the treatment of adult and adolescent patients with mild to moderate atopic dermatitis (AD): A phase-II randomized, double-blind, placebo-controlled study Jon M. Hanifin, MD, Charles N. Ellis, MD, Ilona J. Frieden, MD, Regina Fölster-Holst, MD, Linda F. Stein Gold, MD, Angelo Secci, MD, Angela J. Smith, PA, Cathy Zhao, Ph. D, Elena Kornyeyeva, MD, Ph. D, Lawrence F. Eichenfield, MD Journal of the American Academy of Dermatology Volume 75 Issue 2 Pages 297 -305 (August 2016) DOI: 10. 1016/j. jaad. 2016. 04. 001 Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions Fig 1 Journal of the American Academy of Dermatology 2016 75297 -305 DOI: (10. 1016/j. jaad. 2016. 04. 001) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions Fig 2 Journal of the American Academy of Dermatology 2016 75297 -305 DOI: (10. 1016/j. jaad. 2016. 04. 001) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions Fig 3 Journal of the American Academy of Dermatology 2016 75297 -305 DOI: (10. 1016/j. jaad. 2016. 04. 001) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions Fig 4 Journal of the American Academy of Dermatology 2016 75297 -305 DOI: (10. 1016/j. jaad. 2016. 04. 001) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions Fig 5 Journal of the American Academy of Dermatology 2016 75297 -305 DOI: (10. 1016/j. jaad. 2016. 04. 001) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions Side effects of propranololLiebermanPde 430Definition of differential equationClassification of pdeEma/chmp/cvmp/swp/169430/2012Characteristic equation