Olson M V Human genetics Dr Watsons base

生物信息学 § 人类基因组计划 Ø 数据存储---数据库 Ø 数据分析---数据挖掘 Olson M V. Human genetics: Dr Watson's base pairs[J]. Nature, 2008, 452(7189): 819 -820. § Hap. Map计划 /1000 Genome计划 Ø 大数据

micro. RNA识别 § 2006年诺贝尔奖---RNA干扰机制 § CCCCUCUAUUCACAAUUGUUUGGAACUCAGUUUUGUGAUUAUUCUA UCAUUGCCAGGGAGUUUGUGUGGUUGCAUCAGGGG

micro. RNA分类相关论文 § Chenghai Xue, Fei Li, Tao He, Guo-Ping Liu, Yanda Li, Xuegong Zhang. Classification of real and pseudo micro. RNA precursors using local structuresequence features and support vector machine. BMC Bioinformatics. 2005. 6: 310 (google scholar引用 271次，截至 2014. 8. 2) § Peng Jiang, Haonan Wu, Wenkai Wang, Wei Ma, Xiao Sun, Zuhong Lu. Mi. Pred: classification of real and pseudo micro. RNA precursors using random forest prediction model with combined features. Nucleic Acids Research. 2007, 35: W 339 -W 344 (google scholar引用 239次，截至 2014. 8. 2) § Leyi Wei, Minghong Liao, Yue Gao, Rongrong Ji, Zengyou He, Quan Zou. Improved and promising identification of human micro. RNAs by incorporating a high-quality negative Set. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2014, 11(1): 192 -201

micro. RNA与疾病的关系 § 图挖掘 § 相似度度量、不确定性 参考文献 § § Jiang Q, Hao Y, Wang G, et al. Prioritization of disease micro. RNAs through a human phenome-micro. RNAome network[J]. BMC Systems Biology, 2010, 4(Suppl 1): S 2. Xuan P, Han K, Guo M, et al. Prediction of micro. RNAs associated with human diseases based on weighted k most similar neighbors[J]. Plo. S one, 2013, 8(8): e 70204.

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