Oligomerization and Membranebinding Properties of Covalent Adducts Formed

Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3, 4 Dihydroxyphenylacetaldehyde (DOPAL)* Cristian Follmer, Eduardo Coelho-Cerqueira, Danilo Y. Yatabe-Franco, Gabriel D. T. Araujo, Anderson S. Pinheiro, Gilberto B. Domont, David Eliezer Journal of Biological Chemistry Volume 290 Issue 46 Pages 27660 -27679 (November 2015) DOI: 10. 1074/jbc. M 115. 686584 Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 1 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 2 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 3 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 4 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 5 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 6 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 7 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 8 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 9 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 10 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 11 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 12 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 13 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 14 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 15 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 16 Journal of Biological Chemistry 2015 29027660 -27679 DOI: (10. 1074/jbc. M 115. 686584) Copyright © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions