October 30 2015 TO DO Notebook pencilpen WARM

October 30, 2015 TO DO: Notebook, pencil/pen WARM UP: Pedigree chart HOMEWORK: Weebly reflections on both Genetic Disorders and Sex-linked disease

Sex Linked Genes The Xs and Ys of Genetics

Sex Linked Genes There are 23 pairs of chromosomes and one of those pairs are the sex chromosomes. There are either X chromosomes or Y chromosomes.

Sex Linked Genes These Genes that are chromosomes not carried by either only carry the genes sex chromosome that determine male (X or Y) are said to and female traits, be SEX LINKED but also those for some other characteristics as well.

Males Men normally have an X and a Y combination of sex chromosomes. Since only men inherit the Y chromosome, they are the only ones that inherit Y-linked traits.

Females Women have 2 X chromosomes

X Linked Traits Men and Women can get the X-linked traits since both inherit X chromosomes.

Sex inheritance patterns for male and female children

X Chromosome Traits Men only have one X chromosome Therefore genes on that chromosome are expressed in the male phenotype, even if it is a recessive gene.

X-linked traits May have a In wome, a recessive allele on dominant normal allele on the other one x carriers of X-linked chromosome is traits but more often masked on rarely have them their phenotype expressed in their own phenotypes

X-linked traits In humans, at least 120 genes are known to be X-linked. Genes for hemophilia, red-green color blindness, congenital night blindness, and Duchene muscular dystrophy

Hemophilia An X-linked genetically inherited recessive disease Can not clot their blood Severe bleeding from minor cuts Mostly in males

Red-Green Color Blindness X-linked Cannot perceive red and green in the same Most often afflicts males

Muscular Dystrophy (MD) Characterized by a gradual irreversible wasting away of skeletal muscle. An X-linked trait most often passed on to sons from their mothers. Begins to weaken the legs of boys by age 3 and gets worse every year. No cure and inflicted usually die by age 30.

Y-linked Traits The Y chromosome is small and therefore does not contain many genes Y linked diseases are very rare Only passed from father to son. Example: Male infertility

Hypertrichosis Pinnae. Hairy ears Can happen later in life. Y-linked