Obstructive Sleep Apnea and Ischemic Stroke ZHUZHICHENG Glossary

Obstructive Sleep Apnea and Ischemic Stroke ZHUZHICHENG

Glossary l Ischemic Stroke l Obstructive Sleep Apnea(OSA) l Obstructive Apnea–Hypopnea Index (OAHI) l Polysomnography l Prospective cohort study l Cox proportional hazards model

Obstructive Sleep Apnea Symptoms Definition • Pause in breathing • 10 seconds/hour • Airway obstruction Correlation • High blood pressure • Heart disease • Diabetes • • • Loud snoring Unrefreshed sleep Excessive daytime sleepiness Gasping or choking from sleep Mood change Cognitive dysfunction

Methods—Prospective cohort study l Sample: 5422 (2462 Men + 2960 Women), 8. 7 years l Measurement: Ø Baseline examination: OSA: Apnea–Hypopnea Index(OAHI) Polysomnography Other covariates: BMI, BP, age, race, smoking status, medication, diabetes status, alcohol use, cholesterol, atrial fibrillation Ø First occurrence of stroke: mailing & surveying l Statistical analysis: Cox proportional hazards model

Results

Conclusion There is a significant positive association between ischemic stroke and obstructive sleep apnea in men.

Discussion l Man VS Women: Ø Stroke risk factors, incidence rates, and outcomes differ in men and women. Ø The prevalence of OSA increases more steeply with advancing age in women than men. l Mechanism : Ø Cerebral tissue oxygenation Ø Blood flow regulation Ø Atherogenesis

Reference � Redline S, Yenokyan G, Gottlieb DJ, et al. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study[J]. Am J Respir Crit Care Med, 2010; 182(2): 269 -77.