Observation on therapeutic efficacy of ursodeoxycholic acid in

Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary cirrhosis: a 2 -year follow-up study Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan 1. State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi&#x 02019; an 710032, � China 2. Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi&#x 02019; an 710032, China Fig. 3 Effect of UDCA treatment on histological characteristics. Fourteen PBC patients received liver biopsy before and 2 years after UDCA treatment. Shown are typical cases. (A and C) Before treatment. (B and D) 2 years after treatment. One patient at stage 2 got paired-biopsy pre-(A) and post-treatment (B). Portal inflammatory infiltration lessened significantly after 2 -year treatment. Another patient at stage 4 got paired-biopsy pre-(C) and post-treatment (D). Before treatment, bile duct proliferation (arrowhead in C) and inflammatory infiltration was seen in the portal and bridging necrosis formed. After treatment, bile duct proliferation (arrowhead in D) and portal inflammation were significantly alleviative but bridging fibrosis had still progressed 2 years after treatment.