Number of UK portfolio lung cancer trials Number

Number of UK portfolio lung cancer trials Number of lung cancer trials by UK nation 2014/15 -Q 1&2 2019/20 160 140 120 100 80 60 40 20 Wales Observational Commercial 2 0 /2 19 20 N Ireland Q 1 & /1 9 18 /1 8 20 20 17 /1 7 16 20 /1 6 20 15 /1 5 14 2 20 0 Q 1 & /1 9 20 Scotland Interventional /2 19 20 18 /1 8 20 17 /1 7 16 6 20 /1 15 /1 5 20 14 2 20 Q 1 & 19 /2 0 18 20 20 20 England /1 9 /1 8 17 20 /1 7 16 /1 6 20 15 /1 5 20 14 2 20 /2 0 Q 1 & /1 9 18 19 20 /1 8 17 /1 7 20 16 /1 6 20 15 20 20 14 /1 5 0

Number of UK portfolio lung cancer trials per 100, 000 population Number of lung cancer trials per 100 k population 2014/15 - Q 1&2 2019/20 (excluding commercial trials) Number of lung cancer trials per 100 k population 2014/15 - Q 1&2 2019/20 (including commercial trials) 0. 6 0. 7 0. 5 0. 6 0. 5 0. 4 0. 3 0. 2 0. 1 0 0. 1 2014/15 2015/16 England 2016/17 Scotland 2017/18 Wales 2018/19 N Ireland 2019/20 Q 1&2 0 2014/15 2015/16 England 2016/17 Scotland 2017/18 Wales 2018/19 N Ireland 2019/20 Q 1&2

Recruitment to UK portfolio lung cancer trials Average number of participants per UK lung cancer trial England Scotland Wales Interventional 2014/15 874. 7 122. 8 106. 7 909. 0 132. 3 280. 2 2015/16 941. 9 79. 4 215. 8 2016/17 775. 0 131. 1 129. 1 2017/18 321. 0 102. 8 64. 1 2018/19 59. 7 2. 5 1. 7 Q 1&2 2019/20 Observational 2014/15 1370. 6 2137. 9 718. 5 1397. 9 1940. 1 296. 9 2015/16 1408. 8 953. 0 213. 9 2016/17 1574. 4 1111. 0 594. 0 2017/18 1215. 9 251. 0 213. 5 2018/19 188. 5 50. 0 48. 8 Q 1&2 2019/20 Commercial 2014/15 16. 3 4. 6 1. 0 16. 4 4. 2 2. 3 2015/16 24. 9 4. 5 3. 3 2016/17 9. 0 3. 0 2017/18 10. 6 2. 5 4. 7 2018/19 4 1 1 Q 1&2 2019/20 Cancer recruitment per 100 k graph received from HCRW N Ireland 58. 3 168. 0 0 239. 0 52. 0 1. 0 739. 0 119. 0 295. 0 254. 0 126. 0 4. 0 0 0 1. 5 0 0 0

Number of lung cancer trials in Wales Portfolio trials Number of interventional cancer trials in Wales by region* 2014 - Q 1&2 2019/20 14 12 10 8 6 4 2 0 2014/15 2015/16 North Wales 2016/17 2017/18 South West Wales 2018/19 Q 1&2 2019/20 12 10 8 6 4 2 2014/15 2015/16 2016/17 2017/18 Swansea Bay 1 0 0 0 Powys Cwm Taf 0 0 0 1 1 0 0 Powys Cwm Taf 1 0 0 0 3 2 3 4 3 2 Aneurin Bevan 1 0 1 2 2 1 Cardiff & Vale 0 1 0 0 2 0 Aneurin Bevan 4 4 3 3 3 2 Cardiff & Vale 3 3 2 3 Velindre 6 3 4 5 3 2 South East Number of observational cancer trials in Wales by region* 2014 - Q 1&2 2019/20 0 Number of Interventional trials Betsi Hywel Dda Cadwaladr 2014/15 4 1 2015/16 4 1 2016/17 2 0 2017/18 1 0 2018/19 1 0 2019/20 Q 1&2 0 0 2018/19 Q 1&2 2019/20 Number of Observational trials Betsi Hywel Dda Swansea Cadwaladr Bay 4 3 2 2014/15 2015/16 3 2 1 2016/17 3 2 1 2017/18 2 2 0 2018/19 2 3 0 2019/20 Q 1&2 1 2 0 Velindre 0 1 1 1 observational North Wales South West Wales South East * Where duplicate trials are taking place in the same region, these are only counted once

Number of lung cancer trials in Wales Portfolio trials Number of commercial cancer trials in Wales by region* 2014 - Q 1&2 2019/20 4. 5 4 3. 5 3 2. 5 2 1. 5 1 0. 5 0 2014/15 2015/16 2016/17 2017/18 2018/19 Q 1&2 2019/20 commercial North Wales South West Wales 30 25 20 15 10 5 2014/15 2015/16 North 2016/17 South West Powys Cwm Taf 0 0 0 Powys Cwm Taf 1 0 0 0 4 3 3 4 3 2 Aneurin Bevan 0 1 0 0 Cardiff & Vale 0 1 0 0 Aneurin Bevan 5 5 4 5 5 3 Cardiff & Vale 3 5 3 3 4 3 Velindre 1 1 3 4 3 1 South East Total number of cancer trials in Wales by region* 2014 - Q 1&2 2019/20 0 Number of Commercial trials Betsi Hywel Dda Swansea Cadwaladr Bay 2014/15 0 0 0 2015/16 1 0 0 2016/17 0 0 0 2017/18 0 0 0 2018/19 0 0 0 2019/20 Q 1&2 0 0 0 2017/18 South East 2018/19 Number of all cancer trials Betsi Hywel Dda Swansea Cadwaladr Bay 2014/15 8 4 3 2015/16 8 3 1 2016/17 5 2 2 2017/18 3 2 0 2018/19 3 3 0 2019/20 Q 1&2 1 2 0 Velindre 7 5 8 10 7 4 Q 1&2 2019/20 * Where duplicate trials are taking place in the same region, these are only counted once

Recruitment to lung cancer trials in Wales Portfolio trials Recruitment to cancer trials in Wales by region 2014 - Q 1&2 2019/20 1000 900 Total recruitment to cancer trials 800 2014/15 2015/16 2016/17 2017/18 2018/19 700 Betsi Cadwaladr Hywel Dda ABMU Powys Cwm Taf Aneurin Bevan Cardiff & Vale Velindre 600 500 400 300 200 100 Interventional Observational North South West South East 20 01 9/ /1 9 2 Q 1 &2 20 18 /1 8 20 17 /1 7 20 16 /1 6 15 20 /1 5 14 20 20 2 01 9/ /1 9 18 Q 1 &2 20 /1 8 20 17 /1 7 20 16 /1 6 15 20 20 14 /1 5 0 Commercial 8 4 3 1 4 5 3 7 247 194 104 17 238 171 90 121 150 142 17 0 127 134 85 28 117 94 5 0 69 107 96 30 143 140 0 0 42 79 108 40 2019/20 Q 1&2 17 53 0 0 11 42 49 29

Average recruitment to lung cancer trials in Wales Portfolio trials 5 year average recruitment to lung cancer trials per 100 k population in Wales 2014 -2019 30 25 Wales Average recruitment 2014 - 2018 20 15 10 5 0 North South West South East