Number of UK portfolio haematology trials Number of

Number of UK portfolio haematology trials Number of haematology trials by UK nation 2014 -Q 1&2 2019/20 160 140 120 100 80 60 40 20 England Wales Observational Commercial Q 1 N Ireland 0 /2 19 /1 9 20 18 &2 20 /1 8 20 17 /1 7 16 /1 6 20 15 /1 5 20 0 14 20 /2 19 /1 9 &2 Q 1 Scotland Interventional 20 18 /1 8 20 20 17 /1 7 20 16 /1 6 15 /1 5 20 14 0 /2 20 19 20 /1 9 &2 20 18 /1 8 17 /1 7 20 20 16 /1 6 20 15 /1 5 14 /2 0 20 19 /1 9 20 Q 1 &2 20 18 /1 8 20 17 /1 7 16 /1 6 20 15 20 20 14 /1 5 0

Number of UK portfolio haematology trials per 100, 000 population Number of UK haematology trials per 100 k population 2014 Q 1&2 2019/20 (excluding commercial trials) Number of UK haematology trials per 100 k population 2014 Q 1&2 2019/20 (including commercial and non commercial trials) 1 0. 9 1. 4 0. 8 1. 2 0. 7 1 0. 6 0. 5 0. 8 0. 4 0. 6 0. 3 0. 4 0. 2 0. 1 0 2014/15 2015/16 England 2016/17 Scotland 2017/18 2018/19 Wales N Ireland Q 1&2 2019/20

Recruitment to UK portfolio cancer trials Cancer recruitment per 100 k graph received from HCRW Average number of participants per haematology trial England Scotland Wales Interventional 2014/15 52. 7 13. 7 2015/16 44. 6 10. 4 2016/17 41. 3 10. 1 2017/18 36. 4 7. 6 2018/19 28. 8 3. 8 Q 1&2 2019/20 18. 0 0 Observational 2014/15 67. 4 1. 5 2015/16 66. 3 1. 4 2016/17 149. 2 2. 8 2017/18 139. 9 8. 4 2018/19 79. 4 2. 8 Q 1&2 2019/20 130. 4 2. 0 Commercial 2014/15 10. 0 2. 2 2015/16 11. 8 2. 5 2016/17 14. 4 4. 1 2017/18 20. 0 4. 1 2018/19 19. 4 3. 3 Q 1&2 2019/20 6. 3 5. 0 N Ireland 10. 3 13. 8 7. 1 7. 6 5. 8 11. 7 4. 6 6. 6 7. 1 4. 5 4. 0 1. 0 9. 1 2. 0 18. 0 0. 0 40. 7 1. 5 16. 6 7. 0 10. 0 0 12. 5 0 2. 8 2. 0 3. 5 1. 5 4. 0 3. 5 2. 5 10. 0 3. 4 1. 0 2. 1 1. 0

Number of portfolio cancer trials in Wales Interventional haematology studies in Wales by region* 2014 -Q 1&2 2019/20 Number of interventional trials 35 Betsi Cadwaladr 30 25 20 15 10 5 0 2014/15 2015/16 North 2016/17 South West 2017/18 2018/19 Q 1&2 2019/20 2014/15 2015/16 2016/17 2017/18 2018/19 Q 1&2 2019/20 10 Betsi Cadwaladr 2014/15 2015/16 2016/17 2017/18 2018/19 Q 1&2 2019/20 8 6 4 2 2015/16 North 2016/17 South West 3 4 5 7 0 0 1 2 3 0 5 4 0 0 0 2 2 1 1 0 0 Cardiff & Vale 0 0 1 1 Velindre 12 11 16 13 9 7 0 0 1 0 Number of observational trials 12 2014/15 8 7 6 6 3 3 Aneurin Bevan Cwm Taf South East Observational haematology trials in Wales by region* 2014 -Q 1&2 2019/20 0 Hywel Dda Swansea Bay Powys 2017/18 South East 2018/19 Q 1&2 2019/20 Hywel Dda Swansea Bay Powys 1 3 0 1 0 2 3 1 0 0 1 1 0 0 Aneurin Bevan Cwm Taf 0 0 0 1 2 0 1 0 0 Cardiff & Vale. Velindre 0 1 0 0 4 6 3 2 1 0 0 0 1 1 1

Number of portfolio cancer trials in Wales Commercial haematology trials in Wales by region* 2014 - Q 1&2 2019/20 Number of commercial trials 14 Betsi Swansea Hywel Dda Cadwaladr Bay 12 10 8 6 4 2 0 2014/15 2015/16 North 2016/17 South West 2017/18 2018/19 Q 1&2 2019/20 South East Total haematology trials in Wales by region* 2014 -Q 1&2 2019/20 50 45 40 35 30 25 20 15 10 5 0 2014/15 2015/16 2016/17 2017/18 2018/19 Q 1&2 2019/20 2015/16 North 2016/17 South West 2017/18 South East 2018/19 Q 1&2 2019/20 Aneurin Bevan Cwm Taf Cardiff & Vale Velindre 0 0 1 2 4 3 4 0 0 0 3 0 0 0 0 2 2 6 8 8 0 0 0 0 3 0 0 0 7 0 Total number of trials Betsi Cadwaladr 2014/15 Powys 2014/15 2015/16 2016/17 2017/18 2018/19 Q 1&2 2019/20 Swansea Bay Hywel Dda Powys Aneurin Bevan Cwm Taf Cardiff & Vale Velindre 9 10 7 7 4 5 10 9 12 0 2 3 4 0 8 0 0 0 3 4 2 2 0 0 1 0 0 2 14 17 23 24 19 0 0 0 1 2 4 0 7 0 0 1 15 1

Recruitment to haematology trials in Wales by region Recruitment to haematology cancer trials in Wales by region 2014 2019 Total recruitment to haematology trials in Wales 2014/15 2015/16 2016/17 2017/18 450 400 350 300 250 200 150 100 50 Interventional North South West South East Commercial 0 /2 19 /1 9 Q 1 &2 20 18 /1 8 20 17 /1 7 20 16 /1 6 20 15 /1 5 14 20 Observational 20 0 /2 19 /1 9 Q 1 &2 20 18 /1 8 20 17 /1 7 20 16 /1 6 20 15 /1 5 20 0 14 /2 20 19 /1 9 Q 1 &2 20 18 /1 8 20 17 /1 7 20 16 /1 6 20 15 20 20 14 /1 5 0 Betsi Cadwaladr Hywel Dda Swansea Bay Powys Cwm Taf Aneurin Bevan Cardiff & Vale Velindre 2018/19 Q 1&2 2019/20 56 40 83 85 56 57 40 58 18 0 11 0 84 18 0 50 5 0 31 0 0 7 35 0 0 15 0 0 2 1 0 0 5 1 74 0 125 0 107 0 126 10 101 7 42 11

Recruitment to portfolio cancer trials in Wales Average recruitment to haematology trials per 100 k population in Wales by region (2014 -2019) 12 10 Wales Average recruitment 2014 - 2019 8 6 4 2 0 North South West South East