Nucleotides Nucleic Acids Watson Crick 1953 Franklin Wilkins

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Nucleotides & Nucleic Acids Watson & Crick 1953 (Franklin & Wilkins too) Franklin &

Nucleotides & Nucleic Acids Watson & Crick 1953 (Franklin & Wilkins too) Franklin & Wilkins Heavy bands - indicates recurring bases X - indicates helical structure

Nucleotides & Nucleic Acids Watson & Crick 1953 (Franklin & Wilkins too) Watson &

Nucleotides & Nucleic Acids Watson & Crick 1953 (Franklin & Wilkins too) Watson & Crick Used x-ray crystallography data Used Chargaff’s rules 3 D structure of DNA, strands antiparallel

Nucleotides & Nucleic Acids DNA structure Complementarity Strands not identical in base sequence or

Nucleotides & Nucleic Acids DNA structure Complementarity Strands not identical in base sequence or composition DNA replication

Nucleotides & Nucleic Acids DNA structure - different forms

Nucleotides & Nucleic Acids DNA structure - different forms

A-DNA Z-DNA B-DNA

A-DNA Z-DNA B-DNA

Nucleotides & Nucleic Acids DNA structure - different forms Structure type Pitch (Å) Axial

Nucleotides & Nucleic Acids DNA structure - different forms Structure type Pitch (Å) Axial rise (h) per nt (Å) Groove width (Å) minor major 11 2. 7 Groove depth (Å) minor major 2. 8 13. 5 A 28. 2 2. 56 B 33. 8 3. 38 5. 7 11. 7 7. 5 8. 5 Z 45 3. 7 8. 8 2 3. 7 13. 8 Z-DNA virtually no major groove due to syn-G, pulls C into major grv Pitch = axial rise x repeat (bp/turn) distance for complete turn of helix So for A-DNA 2. 56 Å x 11 bp/turn = 28. 2 Å axial rise (h) distance between bp

purine rotated into major groove

purine rotated into major groove

B-DNA A-DNA + bulge 32˚ tilted upward A-DNA

B-DNA A-DNA + bulge 32˚ tilted upward A-DNA

Triple Helix Intrastrand base pairing

Triple Helix Intrastrand base pairing

Triple Helix using a third strand of DNA Interstrand base pairing Restriction endonuclease

Triple Helix using a third strand of DNA Interstrand base pairing Restriction endonuclease

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Nucleic Acids Nucleic Acids Nucleic acids are polimersNucleic Acids Nucleic Acids Nucleic acids are polimers
Nucleic Acids Nucleic Acids Nucleic acids polymer areNucleic Acids Nucleic Acids Nucleic acids polymer are
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Nucleotides and nucleic acids Nucleotides have three partsNucleotides and nucleic acids Nucleotides have three parts
Nucleic Acids Introduction to nucleotides Nucleotides are nitrogencontainingNucleic Acids Introduction to nucleotides Nucleotides are nitrogencontaining
DNA Nucleic Acids Nucleic Acids DNA Deoxyribo NucleicDNA Nucleic Acids Nucleic Acids DNA Deoxyribo Nucleic
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4 Nucleic acids DNA RNA Watson and Crick4 Nucleic acids DNA RNA Watson and Crick
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Chapter 28 Nucleosides Nucleotides and Nucleic Acids NucleicChapter 28 Nucleosides Nucleotides and Nucleic Acids Nucleic
Chapter 26 Nucleosides Nucleotides and Nucleic Acids NucleicChapter 26 Nucleosides Nucleotides and Nucleic Acids Nucleic
Chapter 28 Nucleosides Nucleotides and Nucleic Acids NucleicChapter 28 Nucleosides Nucleotides and Nucleic Acids Nucleic
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Watson and Crick model of DNA Nucleotides areWatson and Crick model of DNA Nucleotides are
1953 Watson Crick DNA double helix 1970 E1953 Watson Crick DNA double helix 1970 E
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En 1953 James Watson y Francis Crick publicaronEn 1953 James Watson y Francis Crick publicaron
Discovering DNA Watson and Crick 1953 2003 DNADiscovering DNA Watson and Crick 1953 2003 DNA