Nuclear data for production of medical radionuclides Roberto
Nuclear data for production of medical radionuclides Roberto Capote, IAEA NAPC-Nuclear Data Section 15 th Varenna Conference on Nuclear Reaction Mechanisms, 11 -15 June 2018, Villa Monastero, Varenna, Italy 1 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
THANKS TO ALL PROJECT PARTICIPANTS 2 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
Nuclear data needs: medical applications Basic data are often available, but Therapy deficiencies do exist in: ü discrepant experimental crosssection data, ü optimum production routes for I different beams, ü minimization of contaminants/impurities, ü decay data issues: T 1/2, emission probabilities a, b, b+, g, X 131 Control E Tremor Parkinson MSA 111 In-Octr Neurology 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy 153 Sm Diagnostic Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
Intermediate-term Nuclear Data Needs for Medical Applications: Cross Sections and Decay Data Technical Meeting, 22 -26 August 2011, IAEA report INDC(NDS)-0596 plus impact of completed 2012 -2017 CRP Predominantly charged-particle cross sections: CRP measurements and evaluations Decay data: CRP mainly evaluations Diagnostic gamma emitters: • Cross sections – 51 Cr, 64, 67 Cu, 90 m. Y, 99 Mo/99 m. Tc, 97 Ru, 111 In, 123 I, 123 Xe, 123 Cs, 147 Gd (MRI+SPECT), 186, 188 Re, 200, 201, 202 m. Pb, 201 Tl • Decay data ‒ 99 m. Tc (Auger electrons), 123 I (Auger electrons), 147 Gd (MRI+SPECT) Positron emitters: • Cross sections ‒ 11 C, 13 N, 14, 15 O, 30 P, 34 m. Cl, 38 K, 43 Sc, 45 Ti, 48 V, 49 Cr, 52 m, 52 Mn (MRI+PET), 52 Fe, 55 Co, 57 Ni, 61 Cu, 66, 68 Ga, 72 As, 73 Se, 75, 76 Br, 77 Kr, 81, 82 m. Rb, 82 Sr, 86 Y, 89 Zr, 90 Nb, 94 m. Tc, 95 Ru, 110 m. In, 120, 121 I, 152 Tb • Decay data – 52 m, 52 Mn (MRI+PET), 52 Fe, 57 Ni, 64 Cu, 66 Ga, 72 As, 73 Se, 75, 76 Br, 77 Kr, 81, 82 m. Rb, 83 Sr, 86 Y, 89 Zr, 94 m. Tc, 95 Ru, 120, 121 I Positron emitters, generator systems: • Cross sections – 44 Ti/44 Sc, 52 Fe/52 m. Mn (MRI+PET), 62 Zn/62 Cu, 68 Ge/68 Ga, 72 Se/72 As, 82 Sr/82 Rb, 110 Sn/110 m. In, 118 Te/118 Sb, 122 Xe/122 I, 128 Ba/128 Cs, 140 Nd/140 Pr (radiotherapy+PET) • Decay data – 44 Ti half-life, 52 Fe/52 m. Mn (MRI+PET), 62 Zn/62 Cu, 72 Se/72 As, 140 Nd/140 Pr 4 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
IAEA research project 2012 -2017 Ø A. Hermanne, A. V. Ignatyuk, R. C. , B. V. Carlson et al, (22 reactions) Reference Cross Sections for Charged-particle Monitor Reactions Nuclear Data Sheets 148 (2018) 338 -382 Ø F. T. Tárkányi, A. V. Ignatyuk, A. Hermanne, R. C. et al, (21 reactions) Recommended nuclear data for medical radioisotope production: diagnostic gamma emitters, submitted to JRNC (May 2018) Ø F. T. Tárkányi, A. V. Ignatyuk, A. Hermanne, R. C. et al, (69 reactions) Recommended nuclear data for medical radioisotope production: diagnostic positron emitters, to be submitted to JRNC (June 2018) Ø J. W. Engle, A. V. Ignatyuk, R. C. , B. V. Carlson et al, (~15 reactions) Recommended nuclear data for the production of therapeutic radionuclides to be submitted to Nuclear Data Sheets (July 2018) Ø A. L. Nichols, R. C. , M. -M. Bé, B. V. Carlson et al. , Selected and Recommended Nuclear Decay Data for Medical Radioisotope Production (in preparation) 5 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
IAEA Beam Monitor Reactions www-nds. iaea. org/medical/monitor_reactions. html A. Hermanne, A. V. Ignatyuk, R. C. , B. V. Carlson et al, Reference Cross Sections for Chargedparticle Monitor Reactions, Nuclear Data Sheets 148 (2018) 338 -382 6 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
Accelerator production of Mo-99 F. T. Tárkányi, A. V. Ignatyuk, A. Hermanne, R. C. et al, “Recommended nuclear data for medical radioisotope production: diagnostic gamma emitters”, submitted to JRNC (May 2018) 7 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
Accelerator production of Mo-99 F. T. Tárkányi, A. V. Ignatyuk, A. Hermanne, R. C. et al, “Recommended nuclear data for medical radioisotope production: diagnostic gamma emitters”, submitted to JRNC (May 2018) 8 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
Production of 52 m. Mn (T 1/2 = 21. 1 min) and longer-lived parent 52 Fe Applications: 52 m. Mn has been suggested for myocardial and cerebral perfusion imaging, more recently for studies similar to Mn-enhanced neuronal MRI, and for diagnosis in other organ systems - bones, spinal cord and the digestive tract. It is also important for multimode imaging (MRI/PET) 52 m. Mn (21. 1 min): β+ (96. 6%), and E (ke. V)(P (%)): 1434. 092 (98. 2). γ γ 52 Fe (8. 275 h): detected by means of radiation emitted from daughter 52 m. Mn. Evaluations have been made of the 52 Cr(p, n)52 m. Mn and 52 Cr(d, 2 n)52 m. Mn direct production routes and nat. Ni(p, x)52 Fe, 55 Mn(p, 4 n)52 Fe and 50 Cr(α, 2 n)52 Fe reactions for indirect production through decay of the longer-lived parent. 9 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
+ -emitter 10 generator 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy 52 Fe/52 m. Mn Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
+ -emitter 11 generator 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy 52 Fe/52 m. Mn Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
IAEA Nuclear Data Section medical portal: radionuclide production www-nds. iaea. org/medportal/ charged particle route neutron/photon route 12 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
ü Reaction modelling of 125 Te(p, 2 n)124 I 13 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
v Reaction modelling of 124 Te(d, x)124 I Impact of d break-up Impact on CN-formation Elastic break-up: (d, np) d + 124 Te-> n + p +124 Te Inelastic break-up: (d, xn) & (d, p) d + 124 Te -> n + 125 I* ->2 n + 124 I d + 124 Te -> p + 125 Te* (d, p) 14 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
Summary and conclusions Experimental data compilations and data selection, theoretical calculations and final evaluations for each monitor reaction and more than 100 reactions used to produce diagnostic/therapeutic radionuclide(s) completed Nuclear data for radionuclide production available at IAEA medical portal http: //www-nds. iaea. org/medportal/ Evaluated data help define strategies for production of radioisotopes on accelerators Evaluated data ensure safe and efficient production of relevant radionuclides for medical applications Evaluated data should be used for validation of nuclear reaction modelling, e. g. , addressing (d, xn) reaction issues 15 15 th Varenna Conference on Nuclear Reaction Mechanisms 11 -15 June 2018, Villa Monastero, Varenna, Italy Roberto Capote, IAEA Nuclear Data Section e-mail: R. Capote. Noy@iaea. org Web: http: //www-nds. iaea. org
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