Norwalk Calici Viruses fackrelUwindsor ca 12122021 1 Norwalk

Norwalk & Calici Viruses fackrel@Uwindsor. ca 12/12/2021 1

Norwalk Viruses Structure l Classification l Multiplication l Clinical manifestations l Epidemiology l Diagnosis l Control l 12/12/2021 Baron’s Web Site 2

Structure l If the AIDS virus were the size of a basketball, Norwalk wouldn't be much bigger than a softball. 12/12/2021 3

Norwalk Virus Structure ill-defined somewhat lace-like l distinct from the featureless appearance of poliovirus. l l Bar = 50 nanometers 12/12/2021 4

Discovery of Norwalk Virus First recorded epidemic attributed to Norwalk virus occurred in an elementary school in Norwalk, Ohio, in 1968. l Bacteria-free fecal filtrates derived from adult patients were fed to volunteers. l – These volunteers consequently became ill – evidence that gastroenteritis could be induced with a nonbacterial agent. 12/12/2021 5

LAURA BEIL The Dallas Morning News The illness that infected a field of football players last fall is thought to be second only to the common cold as a source of sickness 12/12/2021 6

major cause of epidemic acute and mild gastroenteritis, or diarrhea, l older children and adults. l 12/12/2021 7

Symptoms & Treatment l nausea, vomiting, diarrhea, abdominal cramps – occasionally fever – begin within 40 hours (range 12 72 hours) of consuming contaminated food. l self-limiting illness – usually persists < 48 hours, – can last a long as 1 week 12/12/2021 8

Annual Incidence Viral food borne diseases l Norwalk-like viruses l – 23, 000 l Rotavirus – 3, 900, 000 l Astrovirus l Total Viral food borne 30, 883, 391 Total Microbial food borne incidence – 38, 629, 64 – 3, 900, 000 l Hepatitis A – 83, 391 CDC 12/12/2021 9

NLV Reservoir Thought to be restricted to humans but can occur often in calves (44%) and sometimes (2%) in pigs. l calves and pigs may be reservoir hosts of NLVs. l 12/12/2021 10

Hygiene against diseases transmitted via the fecal-oral route Always wash your hands with soap and water any time you might have touched human or animal feces, changed diapers, cleaned up feces, or gardened. Always wash your hands before eating. l Avoid sex that may involve contact with feces. l 12/12/2021 11

Water Safety Do not drink or swallow water directly from rivers, lakes, streams, pools, or spas, l if you travel abroad you may want to avoid drinking water that has not been boiled. l – boiling drinking water for one minute, will destroy any viruses in it. 12/12/2021 12

DONE!!! 12/12/2021 13