Normal Hyperplasia Dysplasia Tumour H 2 AX 100

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ΜΟΡΦΟΛΟΓΙΚΑ ΣΤΑΔΙΑ ΚΑΡΚΙΝΟΓΕΝΕΣΗΣ Normal Hyperplasia Dysplasia Tumour γH 2 AX 100 50 0 1

ΜΟΡΦΟΛΟΓΙΚΑ ΣΤΑΔΙΑ ΚΑΡΚΙΝΟΓΕΝΕΣΗΣ Normal Hyperplasia Dysplasia Tumour γH 2 AX 100 50 0 1 CHk 2 -p. T 68 100 50 0 1 p 53 100 80 60 40 20 0 p 14 p 21 100 80 60 40 20 0 100 1 2 3 4 1 50 N of samples = 16 0 N H 1 D T

Αναγνώριση της βλάβης της δικλωνικής θραύσης του DNA Genotoxic stress P 53 BP 1

Αναγνώριση της βλάβης της δικλωνικής θραύσης του DNA Genotoxic stress P 53 BP 1 ATM P P ATM 53 BP 1 MRN Complex P γH 2 AX foci

Ionizing radiation Chemotherapeutics Double strand breaks DNA double strand breaks response ATM 53 BP

Ionizing radiation Chemotherapeutics Double strand breaks DNA double strand breaks response ATM 53 BP 1 P P γ-Η 2ΑΧ MDC 1 Mre 11 ATM Nbs 1 Rad 50 T 68 Chk 2 P p 53 P G 1 arrest P P Cdk 2 Cyclin A/E p 21

Replication stress Chemotherapeutics Single strand breaks DNA Single strand break response RPA ad 9

Replication stress Chemotherapeutics Single strand breaks DNA Single strand break response RPA ad 9 R RPA RPA ATRIP Ra d 1 Hus 1 RPA Rfc 2 ATR Rfc 3 Rad 17 Rfc 4 Rfc 5 S 317 Chk 1 S 345 P cdc 25 c P P G 2/M arrest P Cdk 2 Cyclin B P P cdc 25 a P Proteolysis S phase arrest

ΕΠΙΚΟΙΝΩΝΙΑ ΤΩΝ ΣΗΜΑΤΟΔΟΤΙΚΩΝ ΜΟΝΟΠΑΤΙΩΝ Ionizing radiation Chemotherapeutics Double strand breaks Replication stress Chemotherapeutics Single

ΕΠΙΚΟΙΝΩΝΙΑ ΤΩΝ ΣΗΜΑΤΟΔΟΤΙΚΩΝ ΜΟΝΟΠΑΤΙΩΝ Ionizing radiation Chemotherapeutics Double strand breaks Replication stress Chemotherapeutics Single strand breaks DNA damage RPARPARPA R ATRIP 9 ad 1 d a R Rfc 2 ATR Hus 1 Rfc 3 Rad 17 Rfc 4 Rfc 5 γ-Η 2ΑΧ Mre 11 Nbs 1 ATM Rad 50 S 317 T 68 Chk 1 Chk 2 P p 53 P P cdc 25 a P S 345 P cdc 25 c Proteolysis P Cyclin A/E P Cdk 2 G 1 arrest P Cyclin B P Cdk 2 p 21 S phase arrest G 2/M arrest

φάσης Πότε λειτουργούν οι μηχανισμοί επιδιόρθωσης βλαβών του DNA; Μηχανισμός/Φάση G 1 S G

φάσης Πότε λειτουργούν οι μηχανισμοί επιδιόρθωσης βλαβών του DNA; Μηχανισμός/Φάση G 1 S G 2/M NHEJ + + + HR - + + BER + + + NER + + + MMR + + + TSP + TS + NHEJ: Non Homologous End Joining, HR: Homologous Recombination, BER: Base Excision Repair, NER: Nucleotide Excision Repair, MMR: Mismatch Repair, TLS: Translesion Synthesis Polymerases, TS: Template Switch

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Developmental dysplasia of the hip DDH Definition DysplasiaDevelopmental dysplasia of the hip DDH Definition Dysplasia
CARCINOMA CERVIX Moderate dysplasia CIN2 Severe dysplasia CIN3CARCINOMA CERVIX Moderate dysplasia CIN2 Severe dysplasia CIN3
ELBOW DYSPLASIA Dr Murat ALIKAN Canine elbow dysplasiaELBOW DYSPLASIA Dr Murat ALIKAN Canine elbow dysplasia
Bone Dysplasia Definition of Dysplasia Abnormal development TypesBone Dysplasia Definition of Dysplasia Abnormal development Types
Fibrous Dysplasia craniofacial fibrous dysplasia skull and facialFibrous Dysplasia craniofacial fibrous dysplasia skull and facial
Developmental dysplasia of the hip DDH Developmental dysplasiaDevelopmental dysplasia of the hip DDH Developmental dysplasia
Fibrous Dysplasia craniofacial fibrous dysplasia skull and facialFibrous Dysplasia craniofacial fibrous dysplasia skull and facial
FIBROUS DYSPLASIA Fibrous Dysplasia University of Pretoria DEFINITIONFIBROUS DYSPLASIA Fibrous Dysplasia University of Pretoria DEFINITION
27 Tumour immunology tumour antigens mechanisms of defence27 Tumour immunology tumour antigens mechanisms of defence
27 Tumour immunology tumour antigens mechanisms of defence27 Tumour immunology tumour antigens mechanisms of defence
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13 2 1 Hyperplasia Dysplasia Carcinoma in situ13 2 1 Hyperplasia Dysplasia Carcinoma in situ
Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia n 11242020Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia n 11242020
Benign Prostatic Hyperplasia Enlarged Prostate Benign prostatic hyperplasiaBenign Prostatic Hyperplasia Enlarged Prostate Benign prostatic hyperplasia
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100 100 100 25 5010050 25 100 100100 100 100 25 5010050 25 100 100
normal THE NORMAL CHRISTIAN LIFE normal THE NORMALnormal THE NORMAL CHRISTIAN LIFE normal THE NORMAL
Distribucin Normal Distribucin Normal Distribucin Normal Distribucin NormalDistribucin Normal Distribucin Normal Distribucin Normal Distribucin Normal
RECUERDA 100 100 100 90 90 100 16RECUERDA 100 100 100 90 90 100 16
PROSTATE NORMAL STRUCTURE OF PROSTATE NODULAR HYPERPLASIA CARCINOMAPROSTATE NORMAL STRUCTURE OF PROSTATE NODULAR HYPERPLASIA CARCINOMA
First Normal Form Second Normal Form Third NormalFirst Normal Form Second Normal Form Third Normal
Recognizing Cardiac arrhythmias Normal anatomy Normal ECG NormalRecognizing Cardiac arrhythmias Normal anatomy Normal ECG Normal
2 DISTRIBUCIN NORMAL MULTIVARIANTE Introduccin Normal bivariante Normal2 DISTRIBUCIN NORMAL MULTIVARIANTE Introduccin Normal bivariante Normal