Nonsteroidal antiinflammatory drugs for acute low back pain
Non-steroidal antiinflammatory drugs for acute low back pain van der Gaaget al (2020) Trusted evidence. Informed decisions. Better health. This document is licensed under a Creative Commons Attribution Non. Commercial. No. Derivatives 4. 0 International License: http: //creativecommons. org/licenses/by-nc-nd/4. 0/ That means this document can be used and shared as long as IWH is credited as the source, the contents are not modified, and the contents are used for non-commercial purposes. If you wish to modify and/or use the contents for commercial purposes, please contact ip@iwh. on. ca.
NSAIDs for acute LBP van der Gaag et al (2020) Overview of the study Objectives: • To assess the effects of NSAIDs compared to placebo and other comparison treatments for acute LBP Methods: • Evidence current up to 7 January 2020 • Participants: Adults with acute low back pain • Main comparison: NSAIDS versus placebo • Other comparisons: • Selective NSAIDs COX-2 inhibitors versus non-selective NSAIDs • NSAIDs versus paracetamol • NSAIDs versus other drug treatment • NSAIDs versus non-drug treatment • Outcomes: o Primary: Pain, disability, global measure of improvement, adverse events, return to work o Secondary: none
NSAIDs for acute LBP • • van der Gaag et al (2020) Results & conclusions 32 trials (5356 participants) included in the review 9 trials looked at the main comparison Intervention Evidence Quality of evidence NSAIDs slightly more effective than placebo in short term reduction in pain intensity moderate NSAIDs slightly more effective for short term improvement in disability high NSAIDs versus NSAIDs slightly more effective for short term global placebo improvement low No clear difference in proportion of people experiencing adverse events very low No clear difference in proportion of people who could return to work after 7 days very low Ø NSAIDs seem slightly more effective than placebo for short term pain reduction, disability, and global improvement. The magnitude of the effect is small and probably not clinically relevant
- Slides: 3