NMethylNnitroNnitrosoguanidine MNNG Triggers MSH 2 and Cdt 2

  • Slides: 6
Download presentation
N-Methyl-N′-nitro-N-nitrosoguanidine (MNNG) Triggers MSH 2 and Cdt 2 Proteindependent Degradation of the Cell Cycle

N-Methyl-N′-nitro-N-nitrosoguanidine (MNNG) Triggers MSH 2 and Cdt 2 Proteindependent Degradation of the Cell Cycle and Mismatch Repair (MMR) Inhibitor Protein p 21 Waf 1/Cip 1* Thomas Jascur, Rati Fotedar, Serena Greene, Erin Hotchkiss, C. Richard Boland Journal of Biological Chemistry Volume 286 Issue 34 Pages 29531 -29539 (August 2011) DOI: 10. 1074/jbc. M 111. 221341 Copyright © 2011 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 1 Journal of Biological Chemistry 2011 28629531 -29539 DOI: (10. 1074/jbc. M 111.

FIGURE 1 Journal of Biological Chemistry 2011 28629531 -29539 DOI: (10. 1074/jbc. M 111. 221341) Copyright © 2011 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 2 Journal of Biological Chemistry 2011 28629531 -29539 DOI: (10. 1074/jbc. M 111.

FIGURE 2 Journal of Biological Chemistry 2011 28629531 -29539 DOI: (10. 1074/jbc. M 111. 221341) Copyright © 2011 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 3 Journal of Biological Chemistry 2011 28629531 -29539 DOI: (10. 1074/jbc. M 111.

FIGURE 3 Journal of Biological Chemistry 2011 28629531 -29539 DOI: (10. 1074/jbc. M 111. 221341) Copyright © 2011 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 4 Journal of Biological Chemistry 2011 28629531 -29539 DOI: (10. 1074/jbc. M 111.

FIGURE 4 Journal of Biological Chemistry 2011 28629531 -29539 DOI: (10. 1074/jbc. M 111. 221341) Copyright © 2011 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 5 Journal of Biological Chemistry 2011 28629531 -29539 DOI: (10. 1074/jbc. M 111.

FIGURE 5 Journal of Biological Chemistry 2011 28629531 -29539 DOI: (10. 1074/jbc. M 111. 221341) Copyright © 2011 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions