NIHR University College London Hospitals and UCL Biomedical

NIHR University College London Hospitals and UCL Biomedical Research Centre Professor Bryan Williams Chair of Medicine UCL Director; NIHR UCLH/UCL Biomedical Research Centre, Director; Research & Development UCL Hospitals University College London bryan. williams@ucl. ac. uk NIHR University College London Hospitals Biomedical Research Centre

Our vision In five years our BRC partnership will be a world leading Professional Translational Research Organisation Accelerating patient access to medical innovation NIHR University College London Hospitals Biomedical Research Centre VISION

World class Discovery Science 1 NIHR/RAND metrics – biggest aggregation of biomedical science in Europe 1 UK REF 2014 research power and research impact 4 World ranking for preclinical and clinical science (Times Higher 2015) Over 700 BRC publications 2015/16, rising from 200 in 2012 (current BRC H-Index 96, 55, 000 citations) Francis Crick Institute founding partner and its natural translational partner NIHR University College London Hospitals Biomedical Research Centre VISION

World Class discovery science A Strong University / NHS Partnership Alignment of UCL Research Strength with UCLH Clinical Excellence UCLH is a research hospital £ 1. 5 bn Joint capital clinical / research investment in next 5 years Unparalleled access to patients with rare and complex diseases NIHR University College London Hospitals Biomedical Research Centre VISION

World Class discovery science Largest innovative/complex early phase research program in Europe 3 -fold increase in phase I / II trials since 2012; and growing exponentially A Strong University / NHS Partnership Explicit Focus on Experimental Medicine and Translation Leading in UK: MRC early phase trials awards (DPFS) – 25% of all awards 20: 20 Leading in Europe: UCL top for Horizon 20: 20 awards in Health NIHR University College London Hospitals Biomedical Research Centre VISION

Harnessing technological innovation Transforming drug discovery, target identification and validation High Through-Put Platforms (genomic, imaging) with Patient Data linked at scale 1 Computer science Healthcare Engineering and Imaging (REF 2014) UCL Farr Institute – Data Science (Only BRC-affiliated University with a Farr Institute) Partnership with the Alan Turing Institute, Google Deep Mind, e. Med. Lab and EBI e. Med. Lab – high performance computing cluster for genomic, imaging and patient data NIHR University College London Hospitals Biomedical Research Centre VISION

High Through-Put Platforms TREACC – Professional support for Translational Research and commercialisation (genomic, imaging) with Patient Data linked at scale Enterprise culture Industry Partnerships Creating Value £ 100 m Syncona investment into UCL in past year £ 100 m UCL Technology and Apollo Start-up funds £ 600 m Leveraged in current BRC in 5 years (£ 8: 1) 3 Major Pharma embedded industry partners for drug discovery (Takeda, Eisai, and GSK) NIHR University College London Hospitals Biomedical Research Centre VISION

High Through-Put Platforms (genomic, imaging) with Patient Data linked at scale Enterprise culture Industry Partnerships Creating Value Building Resilience Training the next generation of Experimental Medicine Leaders The BRC Experimental Medicine Academy BRC supported Ph. D students increasing from 101 (2012) to 315 (2015) >90% conversion to fellowships NIHR University College London Hospitals Biomedical Research Centre VISION

NIHR University College London Hospitals / UCL Biomedical Research Centre Existing Themes Neuroscience Dementia Nicholas Wood Cross-cutting Themes Cancer Martin Rossor Mental Health Deafness and Hearing Robert Howard Anne Schilder Emma Morris David Linch Oral Health & Disease Cardiovascular Aroon Hingorani 3 1 1 Immunity, Inflammation & Immunotherapeutics BRC Director Bryan Williams Infection & Antimicrobial Resistance Stefano Fedele Sharon Peacock Obesity Rachel Batterham UCL Therapeutic Innovation Network Bart Vanhaesebroeck Health Care Engineering and Imaging Sebastian Ourselin Health Care Informatics, Genomics, “-omics” & Data Science BRC Education and Training Program – The BRC Academy Translational Research and Enterprise Accelerator (TREACC) Public Involvement, Engagement and Communications NIHR University College London Hospitals Biomedical Research Centre New Themes Harry Hemingway Geraint Rees David Lomas Simon Denegri THEMES

UCLH UCL Partners Academic Health Sciences Centre NIHR UCLH CRF Global Academic Industry Partnerships BRC Academy in Experimental Medicine Discovery Science Genomics Proteomics Metabolomics Wolfson and Alzheimer’s UK Drug Discovery Institutes National Pan-NIHR Bioresource TRCs NIHR HIC Bloomsbury Research Institute Farr Institute for Informatics Patient & Public Involvement & Engagement Patients Embedded Industry Partnerships Pan UCL AHSC GOSH BRC Moorfields BRC Sir Francis Crick Institute Clinical Translation Imaging & Health Care Engineering Alan Turing Institute Translational Research & Enterprise Accelerator Cancer Research UK Centre Therapeutic Innovation Networks Health Care Informatics & Data Science UCL Computer Science Google 7 MRC Centres Deep Mind UCL NIHR University College London Hospitals Biomedical Research Centre BRC RESEARCH ECOSYSTEM

World Class Science Transforming Patients’ Lives 1000 new phase I/II Trials Accelerating Patient Access Create 30 new companies new treatments for many previously intractable diseases Vanguard for Vanguard treatments for Cancer Proton Beam National Centre for Cancer Immunotherapy Innovative treatments for dementia and neurological diseases Identifying and Targeting the disease pro-drome Disruptive innovation in Cellular and Gene therapies Applied engineering for diagnostics and imaging the leading centre in Europe precision medicine NIHR University College London Hospitals Biomedical Research Centre Genomics / omics platforms Applied engineering for with patient data diagnostics andlinkage imagingat scale Innovating andmedicine Repurposing precision Embedded industry partnerships - drug discovery the human as the experimental model Inward investment We will leverage £ 1 bn Creating Health and Wealth WHAT WE WILL DELIVER