NIH Career Development Awards Workshop NIH Career Transition
- Slides: 103
NIH Career Development Awards Workshop NIH Career Transition Awards: Enabling Your Success Joan M. Lakoski, Ph. D. University of Pittsburgh Vanderbilt University Medical Center November 16, 2006
NIH Career Transition Awards GOAL: • To provide guidance on applications for NIH career development (“K”) awards of relevance to basic scientists, including the NIH Pathway to Independence (K 99/R 00) Award
Workshop Objectives By the completion of this session, participants should be able to • Choose the appropriate type of K Award for their career stage & situation. • Complete an application for a NIH career transition award. • Submit an application using strategies for a successful grant proposal.
Workshop Overview • • • Navigating NIH Inside the Study Section Process Anatomy of an Application 15 Steps to the Payline Questions & Discussion
NIH Career Transition Awards Understanding NIH http: //www. nih. gov/about/maps. html
Navigating NIH • Structure of NIH • Grant reviews • The Study Section Poster by L. Azzinaro http: //www. nih. gov/od/museum/exhibits/history/
National Institutes of Health (NIH) • Agency of the US Public Health Service • Mission: research, training, education • 19 Institutes + other components • Director: Elias Zahouni, M. D. • Budget (FY 06) = $28, 845 million
National Institutes of Health (NIH) Functional Divisions: Intramural Research Program – research within NIH Institutes: ~10% budget – administration & support: ~9% budget Extramural Research Program – external research & training: ~81% budget
NINDS — a typical Institute National Institute of Neurological Diseases & Stroke (NINDS) Advisory Council: – oversees institute Division of Intramural Research: – NINDS research labs in Bethesda Division of Extramural Research: – grants & contracts for external research
NINDS — a typical Institute Division of Extramural Research: • organized into Programs – each responsible for an area of research • Program Officers: – administer funded grants in their area Cultivating the interest and support of program officers is essential!
NIH — Extramural Support Research Project Grants (~50% budget): R 01: single investigator P 01: Program Project Other Types: Center Grants: 9% budget Contracts: 9% budget
NIH — Career Development Awards K Awards: • support for career development • ~ 2% budget: $624 million (FY 06) • wide range of types: – currently 14 (K 01 -K 99) • for clinicians & basic scientists • for junior & senior faculty
NIH: grant/career timeline student post doc resident junior faculty senior faculty training: F 31 F 32 K Awards (career dev) research: R 01 P 01
K Awards Why should you be interested? • K awards: – foster basic, clinical & patient-oriented research – provide partial funding for salaries
K Awards Success Rates: all K awards
K Awards For mentored career development: • clinicians: K 08, K 23, K 24 • basic scientists: K 01 For career transition: • basic scientists: K 02, K 22 • Pathway to Independence: K 99/R 00
NIH Grants: Information General: http: //www. nih. gov/grants/guide/index. html • search on mechanism of interest and applicable institute K Awards: “K kiosk” http: //grants 1. nih. gov/training/careerdevelopmentawards. htm
NIH Grants: Information Distribution of K Awards by NIH Institute Contact the appropriate Program Officer first!
K Awards Mentored career development: • development of junior faculty • dedicated mentor is essential for – successful application – successful outcome • clinicians & basic scientists
K Awards: for basic scientists Ph. D. Postdoc. Faculty —> K 01 K 02 Independent investigator Mentored Research Scientist Award Independent Scientist Award Career Transition K 22 Award
K Awards for basic scientists K 01: Mentored Research Scientist Award — career development in a new area of research • potential for productive independent research • mentor with extensive research experience • 75% effort over 3 -5 years • differences among Institutes images © 2002 www. arttoday. com
K Awards for basic scientists K 02: Independent Scientist Award — develop career of funded scientists • salary support for newly independent scientists • must have peer-reviewed research support • 75% effort for 5 years images © 2002 www. arttoday. com
K Awards for basic scientists K 22: Career Transition Award — support for postdoctoral fellows in transition to faculty positions • potential for productive independent research • differences among Institutes: may involve training in intramural NIH programs images © 2002 www. arttoday. com
K Awards for basic scientists Success rates:
NIH Career Transition Awards NIH Pathway to Independence (PI) Award Program (PA-06 -133) K 99/R 00 (Kangaroo) Award • Designed to facilitate receiving an R 01 award earlier in an investigator’s research career
First Major Independent Research Support Occurs at an Ever-Later Age Average Age of Initial Type 1 R 01/R 23/R 29 Award for Different Degrees Held 44 45 44 M. D. -Ph. D. 42 41 M. D. 40 40 Ph. D. 39 38 38 37 37 36 35 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 Fiscal Year For more information, see http: //grants. nih. gov/grants/20040712_New_Investigator_Talk. ppt Average 42 43
Developing a Successful K 99/R 00 Application Overall Goal of Initiative To facilitate a new investigator’s ability to transition from a postdoctoral status to an independent scientist capable of applying for an receiving their first R 01 and securing a stable research position
Facilitating the grant/career timeline student post doc resident junior faculty senior faculty training: F 31 research: F 32 K Awards (career dev) Combining the K and R R 01 P 01
K 99/R 00 Award • Provides up to five years of support consisting of two phases: – Initial 1 -2 years of mentored support for highly promising postdoctoral research scientists (K 99 Phase) – Followed by up to 3 years of independent support contingent on securing an independent research position (R 00 Phase)
Mentored (K 99) Phase • Will provide 1 -2 years for mentored support for highly promising postdoctoral research scientists who have terminal clinical or research doctorates • Total cost per year up to $90, 000 • This phase may be submitted on behalf of candidate by wide range, but not foreign institutions • U. S. citizens and non-U. S. citizens eligible
Independent Investigator (R 00) Phase • Transition from K 99 to R 00 (years 3 -5) is to be continuous in time • Activation of R 00 Phase requires offer and acceptance of a tenure-track, full time assistant professor position (or equivalent) • Transition is subject to administrative review of progress and evaluation of research plan
Independent Investigator (R 00) Phase • Application may be submitted on behalf of PI by universities etc but not Federal and foreign institutions • Total cost for independent investigator phase may not exceed $249, 000 per year • Institution must demonstrate commitment to candidate (minimum 75% effort, space, etc. ) • PI expected to apply for independent research grant support
Current Status of NIH Pathway to Independence Awards* • Number of applications received – April 7 = 445 – June 1 = 229 • Number of Awards Anticipated = 177 • Success rate = 40% * Excludes data from October 1 2006 submission deadline
Review Criteria: Mentored (K 99) Phase 1. Candidate 2. Career development plan 3. Research plan 4. Mentor 5. Environment & Institutional Commitment to the Candidate 6. Training in Responsible Conduct of Research 7. Letters of Reference and Mentor(s) statements 8. Plans to Evaluate Progress
Comparison of K 22 and K 99/R 00 Awards K 22 K 99/R 00 Transition Award (postdoc to faculty)? Yes Duration? Varies by IC NIH: 5 yrs U. S. Citizenship/ Green card? Required Not Required Mentored Phase Varies by IC 2 yr Independent Phase Varies by IC 3 yrs Awardee can go to foreign institution? No No Cost Varies by IC $90 K yrs 1 -2 (TC) $747 K yrs 3 -5 (TC) F & A Costs 8% Up to 50%
Know Your K: Navigating NIH • Structure of NIH • Grant reviews • The Study Section http: //www. csr. nih. gov/about. htm
The Grant Triangle Investigator application 1 6 funding Home Institution 2 Study NIH Section 5 3 Council 4 Program NIH Institute 1. an 2. 3. 4. 5. 6. aapplication the NIH application Institute home study institution is. Program section Council submitted is initiated reviews administers decides sends to&NIH prepared funding the whether through proposal the for byto an the & fund the grant investigator’s grant the for score grant the to the isinvestigator sent home to ainstitution NIH institution Institute
The Grant Review Process Important Concepts: • applications must be submitted from a recognized institution • each application has two independent reviews within NIH: “Dual Review” • funding goes to the investigator’s home institution not the investigator
The Grant Review Process Dual Review: 1. Study Section: • scientific merit • written review & score 2. Institute Council: • significance, programmatic merit • approval for funding
The Grant Review Process Center for Scientific Review (CSR): • independent unit within NIH – separate from Institutes • administers review panels (Study Sections) • receives & assigns applications: – to Study Sections for review – to Institutes for funding http: //www. csr. nih. gov/welcome. htm
Know Your K: Navigating NIH • Structure of NIH • Grant reviews • The Study Section images © 2002 www. arttoday. com • http: //www. csr. nih. gov/welcome. htm
The Study Section Members: – working scientists (~15 -20) – one member serves as Chair Scientific Review Administrator (SRA) – NIH (CSR) staff person – assigns grants to reviewers, collates reviews Meetings: – 1 -2 days, 3 times per year
The Study Section Assignments: – primary & secondary: written reviews – tertiary (“reader”): read & comment Review Criteria – defined for each application type Priority Scores: – scale: 100 (best) to 500 (worst)
Sequence of Review • moderated by Chair • reviewers indicate enthusiasm • primary & secondary reviewers present • tertiary reviewer comments • open discussion • members score application • SRA writes summary of discussion
Review Criteria: Mentored (K 99) Phase 1. Candidate 2. Career development plan 3. Research plan 4. Mentor 5. Environment & Institutional Commitment to the Candidate 6. Training in Responsible Conduct of Research 7. Letters of Reference and Mentor(s) statements 8. Plans to Evaluate Progress
The Next Steps Reviews: – collated by SRA & sent to Program Officer, who sends to applicant (“pink sheets”) Payline: – determined by funding available to Institute Council: – sets payline, approves grants for funding Funding: – Notice of Award sent to applicant
NIH Career Transition Awards Anatomy of an Application
Application Package: PHS 398 Download forms: http: //grants 1. nih. gov/grants/funding/phs 398. html – use for Oct 2006 & Feb 2007 deadlines – electronic submission: June 2007
Application Package: PHS 398 Instructions: – download from same source – includes additional instructions for K Awards Read the Instructions! Consult with an interested Program Offi Off
PHS 398: General Instructions Format: • single-sided, single-spaced • only material that can be photocopied – photographs etc —> Appendix • number pages consecutively • specific fonts & sizes required Applications that do not conform may be returned without review!
K Award Application: Face Page Candidate’s name Candidate’s signature
K Award Application: Page 2 Abstract: • career goals • development plan • research project
K Award Application: Page 2 (cont) Key Personnel: • candidate • mentor
K Award Application: Page 3 Table of Contents: • must use substitute page for K Awards • lists special information required for application
K Award Application: Two sections Section I. Basic Administrative Data Section II. Specialized Information
K Award Application: Page 5 Budget: • only complete page 5: budget for entire period • consult with Program Officer about allowed expenses • justify budget
K Award Application: Biosketch Must include: • Education • Research and/or professional exp. • Employment • Honors • Professional Societies • Publications
K Award Application: Other Support • biosketch for mentor must include list of research support relevant to candidate’s research plan
K Award Application: Resources • important to establish feasibility of candidate’s research project
K Award Application: Section II Specialized Information: • Candidate • Statement by Mentor • Environment & Institutional Commitment • Research Plan
Preparing a Successful K 99/R 00 Application • Write to the review criteria • Applicants are advised to distinguish the research components for the K 99 and R 00 phases: separate research projects (and specific aims) into 2 phases
Review Criteria: Mentored (K 99) Phase 1. Candidate 2. Career development plan 3. Research plan 4. Mentor 5. Environment & Institutional Commitment to the Candidate 6. Training in Responsible Conduct of Research 7. Letters of Reference and Mentor(s) statements 8. Plans to Evaluate Progress
K Award Application: Section II The Candidate: • Candidate’s Background — additional information not in biosketch • Career Goals & Objectives —“Scientific Biography” — how training will fit career development • Career Development/Training Activities — new skills & knowledge to be learned — must include training in Responsible Conduct in Research (RCR)
K Award Application: Section II Statement(s) by Sponsor/Mentor: • Description of Training Program — include activities other than research — sponsor’s experience as mentor — concurrent responsibilities — assurance of release from duties — source of support for research project • List other collaborators, consultants — letters from each
K Award Application: Section II Environment & Institutional Commitment: • Description of Institutional Environment — strong relevant research program — availability of resources — intellectual interactions • Institutional Commitment — adequate support from institution — adequate resources — commitment to candidate
K Award Application: Section II Institutional Commitment: • The applicant organization must agree to — release the candidate from other duties to devote the required effort to the program — provide the candidate with appropriate resources (lab, office, equipment etc) — provide time & support for the sponsor • Agreement must be signed by appropriate Institutional Official
K Award Application: Section II Research Plan: • Statement of Hypothesis & Specific Aims • Background, Significance & Rationale • Preliminary Studies & Any Results • Research Design & Methods
Crafting a Successful Proposal Communication! • • Why is this study important? Are the experiments feasible? What will be accomplished? How will it change the field? Keep it simple, concise & logical!
Crafting a Successful Proposal Communicate to your audience:
Crafting a Successful Proposal Design a clear experimental plan: • • • have a clearly stated, testable hypothesis keep the proposal focused indicate outcomes: outcomes what will you learn? anticipate pitfalls; pitfalls outline alternatives provide a timeline: timeline limit the experiments to what can be accomplished within the time period
K Award Application Reference Letters: • required for K 01, K 08, K 22, K 23 and K 99 (mentored) applications • three (3) letters from individuals other than those involved in the application — i. e. , not sponsor/mentor or collaborators • should address candidate’s competence & potential as an independent investigator
K Award Applications Reference Letters: • new guidelines include form letter to request letters of reference
Tips for Best Reference Letters • develop effective working relationships with potential referees • keep your referees updated on your progress • make your referees’ job easy, provide: – current CV, reprints – draft of proposal Remember: this is a personal & professional relationship that may last your entire career
K Award Application: Appendix can include: • material that cannot be photocopied • up to 6 reprints or preprints of papers • need 5 collated sets Assume that reviewers may NOT read appendix material!
K Award Application: Submission Application package must include: • original application, with required signatures • 5 exact copies (single-sided) of the complete application • at least 3 sealed letters of reference • 5 collated sets of appendix material
K Award Application: Submission Deadlines & Review Cycles: Receipt Review Council Start Feb 1 June-July Sept-Oct December June 1 Oct-Nov Jan-Feb April October 1 Jan-Feb May-June July • applications must be received by or mailed on or before the receipt date • proof of mailing: postmark or dated receipt from mail carrier
Electronic Grant Submission • fully electronic submission process – through Grants. gov website • being phased in: – February 2007: R 01 – June 2007: K awards – August 2007: Fellowship Awards • for more information see: http: //era. nih. gov/Electronic. Receipt/
Review Criteria: Mentored (K 99) Phase 1. Candidate 2. Career development plan 3. Research plan 4. Mentor 5. Environment & Institutional Commitment to the Candidate 6. Training in Responsible Conduct of Research 7. Letters of Reference and Mentor(s) statements 8. Plans to Evaluate Progress
NIH Career Transition Awards 15 Steps to the Payline images © 2002 www. arttoday. com
15 Steps to the Payline Step 1 Start the Application • An Idea • A Mentor • An Institution
15 Steps to the Payline Step 2 Have the Right Attitude images © 2002 www. arttoday. com
15 Steps to the Payline Step 3 Find Information & Make Connections
15 Steps to the Payline Step 4 Frame the Question Specific Aims A Testable Hypothesis
15 Steps to the Payline Step 5 Define the Goals Research & Training Programs What you’ll accomplish What you’ll learn
15 Steps to the Payline Step 6 Contact References
15 Steps to the Payline Step 7 Stock the Reservoirs Specific Aims Background & Significance Experimental Plan
15 Steps to the Payline Step 8 Write the First Draft images © 2002 www. arttoday. com
15 Steps to the Payline Step 9 Build a Model Specific Aim # 1 Specific Aim # 2 Specific Aim # 3 from Dazzle’Em With Style Robert Anholt
15 Steps to the Payline Step 10 Get Feedback Mentor Student Applicant Advisor Colleague Faculty
15 Steps to the Payline Step 11 Comply with the Regulations Assurances/Certifications • Human Subjects • Animal Welfare • • “Blue Sheet”
15 Steps to the Payline Step 12 Manage your Mentor Sponsor’s Checklist X Mentor’s Statement X Environment & Institution X Feedback on draft
15 Steps to the Payline Step 13 Proof & Check
15 Steps to the Payline Step 14 Submit the Proposal http: //www. fedex. com/us/about/justforyou/journalists/photos. html
15 Steps to the Payline Step 15 Move Forward Reject The Decision Reapply Funded
K Awards: Review Criteria 1. Candidate 2. Career development plan 3. Research plan 4. Mentor 5. Environment & Institutional commitment 6. Budget
15 Steps to the Payline Checklist:
NIH Career Transition Awards Acknowledgements: Dr. Robert J. Milner Office of Professional Development Penn State College of Medicine The Office of Academic Career Development University of Pittsburgh Schools of the Health Sciences
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