Neurobiology of Schizophrenia Mood Disorders and Anxiety Disorders

Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders Chapter 18 1

Schizophrenia o o o Schizophrenia is a term coined by Eugene Bleuler in 1911 to describe a collection of illnesses characterized by thought disorders Psychotic episode Genetic predisposition n o o Prenatal and perinatal Neuroanatomic alterations Neurotransmitter alterations 2 Mosby items and derived items © 2006 by Mosby, Inc.

Schizophrenia 3 Mosby items and derived items © 2006 by Mosby, Inc.

Schizophrenia 4 Mosby items and derived items © 2006 by Mosby, Inc.

Schizophrenia o Clinical manifestations n n n Hallucinations Delusions Disorganized behavior o o n Disorganized speech Disorganized behavior Negative symptoms o o Affective flattening Anhedonia, alogia, and avolition 5 Mosby items and derived items © 2006 by Mosby, Inc.

Mood Disorders o o Mood refers to a sustained emotional state Affective states are brief emotional feelings n o Euphoria, joy surprise, fear, sadness, etc. Depression n States such as sadness become prominent 6 Mosby items and derived items © 2006 by Mosby, Inc.

Mood Disorders o Categories of mood disorder n Unipolar o n o o Also known as major depression or clinical depression Bipolar disorder Genetic predisposition Environmental influences 7 Mosby items and derived items © 2006 by Mosby, Inc.

Mood Disorders o o Neurochemical dysregulation Neuroendocrine dysregulation n n o Hypothalamic-pituitary-adrenal system dysregulation Hypothalamic-pituitary-thyroid system dysregulation Neuroanatomic and functional abnormalities 8 Mosby items and derived items © 2006 by Mosby, Inc.

Mood Disorders o Clinical manifestations n n o Depression Mania Treatment n n n Antidepressants Psychotherapy Combination of both 9 Mosby items and derived items © 2006 by Mosby, Inc.

Mood Disorders 10 Mosby items and derived items © 2006 by Mosby, Inc.

Mood Disorders 11 Mosby items and derived items © 2006 by Mosby, Inc.

Anxiety Disorders o o Panic disorder Generalized anxiety disorder Posttraumatic stress disorder Obsessive-compulsive disorder 12 Mosby items and derived items © 2006 by Mosby, Inc.