Necroptosis controls NET generation and mediates complement activation

  • Slides: 6
Download presentation
Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis. Schreiber

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis. Schreiber A, Rousselle A, Becker JU, von Mässenhausen A, Linkermann A, Kettritz R. Proc Natl Acad Sci U S A. 2017 Nov 7; 114(45): E 9618 -E 9625

ANCA induces NET generation in human neutrophils by RIPK 1 -dependent necroptosis signaling. ANCA

ANCA induces NET generation in human neutrophils by RIPK 1 -dependent necroptosis signaling. ANCA (Autineutrophil cytoplasmic antibody) PR 3/MPO ANCA target antigen Neutrophils activation Endothelial damage Vasculitis, Glomerulonephritis Necroptosis 가 NET에 관여하는지 3

ANCA induces NET generation in human and murine neutrophils by RIPK 1 - and

ANCA induces NET generation in human and murine neutrophils by RIPK 1 - and MLKL-dependent necroptosis signaling. Positive cont. p-MLKL IHC Staining

ANCA-stimulated necroptosis-dependent NET generation induces NCGN. ANCA-stimulated necroptosis in circulating BM-derived cells induces NCGN.

ANCA-stimulated necroptosis-dependent NET generation induces NCGN. ANCA-stimulated necroptosis in circulating BM-derived cells induces NCGN.

Complement fixation test complement fixation test The complementComplement fixation test complement fixation test The complement
2s Complement form 1s complement form 2s complement2s Complement form 1s complement form 2s complement
MLKL the Protein that Mediates Necroptosis Also RegulatesMLKL the Protein that Mediates Necroptosis Also Regulates
Controls Assessing Controls 2020 Whats are Controls ControlsControls Assessing Controls 2020 Whats are Controls Controls
Concepts Complement activation pathways COMMON TERMINAL PATHWAY ACTIVATIONConcepts Complement activation pathways COMMON TERMINAL PATHWAY ACTIVATION