NE CENTER FOR NEUROLOGICAL DISORDERS Group Members Tsuneya

NE CENTER FOR NEUROLOGICAL DISORDERS • • • Group Members Tsuneya Ikezu - Dept of Pharmacology - UNMC Yutong Liu -Dept of Radiology - UNMC Li Tan - Engineering Mechanics - UNL Luwen Zhang - Virology Center - UNL David Holtzclaw - Dept of Physiology - UNMC Yazen Alnouti - Dept. of Pharmaceutical Sci - UNMC Ron Cerny - Dept. of Chemistry - UNL David Berkowitz - Dept of Chemistry - UNL

Charge: • Your task is to develop core ideas/projects for an $8 -10 M ($1. 25 -1. 5 M per year for 5 years) NIH Center proposal. • Specifically, you should consider the following questions

Briefly describe the core projects your group would design for the Center. Please dream big. • Alz-Novel Druggable Target 1: Identification of the first inhibitors for Tao-Tubulin Kinases (TTBK) I and II (I-Alzheimers, II-Spinocerebellar ataxia) -Ikezu • Alz-Novel Druggable Target 2: Identification of the first inhibitors for Serine Racemase (h. SR) (Alzheimers, stroke)-Berkowitz • CNS-Lymphoma: Interferon Regulatory Factor-4 (IRF 4) as novel transcription factor/emerging lymphoma target-Zhang • Novel Approaches to Neuro-Imaging Use of Mn-, Gd- and Fe-based paramagnetic contrast agents for neuro-MRI (50 u. M resolution/stroke model) -Liu, fluorescence with novel self-assembled agents- Tan • Drug Metabolism/Optimization Cyt-P 450 -based drug candidate metabolism - hot spot/byproduct identification by LC/MS-Alouti, Cerny

Identify the key faculty from both campuses to involve in these projects. Include their strengths. (UNMC on next slide) • UNL Faculty David Berkowitz Li Tan Ron Cerny Luwen Zhang Pat Dussault James Takacs Strengths Enzyme Inhibitor Development Novel Fluorescent Materials NE Proteomics Center Director NE Virology - Lymophoma Medicinal/Natural Prod Chem

Identify the key faculty from both campuses to involve in these projects. Include their strengths. • UNMC Faculty Tsuneya Ikezu Howard Gendelman Yazen Alnouti Yutong Liu David Holtzclaw Hong Sun Strengths Neurodegen Disorders Nanomedicine Drug Metab/Pharmacokinetics Radiology/MRI Fluid Mechanics Rat Stroke Model (Physiol)

Identify external academic partners & expertise or equipment resources/strengths that are needed to accomplish these projects. Harvard Neurodegenerative Disorder Program (High throughput drug screening) UNMC MRI Center ( Liu) NE Center for Proteomics (Cerny) KU cpd library & HTS facility (Scott Wier)

List potential industry/foundation partners (think broadly) and what they would contribute. Include reasons why they would be interested. Neumedix - Australia/Cayman Islands (VC interest in TTBK inhibition with Prof. Ikezu) Merck, Wyeth-Pfizer, Astrazeneca, GSK, BMS (Drug development for Alzheimers, stroke and CNS-lymphoma)

Describe how you would link the Center to other campus resources.