NBC COLLOQUIUM DNA Tetrahedron for Biomedical Applications Speaker
NBC COLLOQUIUM DNA Tetrahedron for Biomedical Applications Speaker : Dae-Ro Ahn, Ph. D. Center for Theragnosis & Department of Biological Chemistry, KIST The biomedical technologies utilizing DNA nanomaterials, including molecular imaging tools and nanomedicine, have immense potential to be successfully adopted in translational research. As a DNA-derived nanomaterial, self-assembled DNA nanostructure is a very attractive platform because its size and shape can be precisely controlled by using the base complementarity of DNA. While various types of DNA nanostructures have been previously reported, biomedical application of them is still in its infancy. Moreover, in vivo utility of the DNA nanomaterial-based biomedical technology has been scarcely demonstrated. In this regard, much of our work focuses on the development of functional DNA nanomaterials for biomedical research, especially for in vivo uses including molecular imaging, tumor targeting, and drug delivery. Among known DNA nanostructures, the DNA tetrahedron has been considered one of the most practical DNA nanostructures since it can be self-assembled simply from four DNA strands and prepared in a high yield. We employ DNA tetrahedron derivatives as a carrier for delivery of biologically interesting molecules such as anticancer agents, proteins, and therapeutic oligonucleotides to the desired loci in the in vivo system. In this presentation, the recent research achievement using the DNA tetrahedron in drug delivery into multidrug-resistant cells, SLN imaging, and delivery of a therapeutic aptamer will be introduced. 4: 00 PM on Sep. 26(Thursday) Engineering Building 1, E 104 Prof. Hyun-Woo Rhee(2551, rhee@unist. ac. kr) NBC Office (2642, aekang@unist. ac. kr)
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