Nature creates we refine Nature Creates We Refine

Nature creates – we refine Nature Creates – We Refine

Suomen Rehu has long experience from functional feed ingredients Expansion of product range and export areas Export of Progut Progres Progut Rumen Export to Scandinavia, Baltic countries, Russia, Taiwan 1994 International business activities, silage preservatives International business activities, enzymes 1999 Progut yeast hydrolysate Development of antibiotic replacement in piglet feeds Special feeds for better rumen function Biological silage preservatives 1980’ies Enzymes for poultry and piglets feeds in Finland Feed enzyme development Nature Creates – We Refine

Drivers and targets for feed and ingredient development Production performance Animal health and wellbeing Food quality and safety Environment Feeding costs Antimicrobial resistance Animal welfare Production structure and disease challenge ”Animal health and productivity starts in the gut” ”Utilization of industry side-streams” Nature Creates – We Refine

Screening tube research model Compounds from industry side-streams Purpose, potential functions Availability, high volume, low price Development of new methods Simulators Test tubes Animal models and clinical trials Product with desired functional properties Nature Creates – We Refine

Development of Progut® and Progres® Prevention of weaning diarrhea Compounds to prevent E. coli growth and stimulate immunity Blood, larch tree extract Peat Brewery yeast waste Simulators Bacterial growth inhibition and attachment assays Rat trials, performance and challenge trials Prevention of Gram+ pathogens Compounds to prevent Gram + growth and improve feed efficiency Bark, knot-wood, tall oil other forest industry side streams Nature Creates – We Refine

. • A naturally occurring product from coniferous forests which is extracted as a by-product of the pulp manufacturing industry. The final refined product contains modified tall oil fatty acids and standardized amount of resin acids. • We have develop this by-product into a specific concentration of resin acids and tall oil fatty acids which have never before been used in animal feeds • Potential – To improve efficiency of meat production systems – To reduce reliance on antibiotics • Patent protected product and applications Nature Creates – We Refine

Market Need • Global meat production will need to double by 2050 to cater for a rising population (FAO). • Need for improved feed efficiency and environmental sustainability • As production systems intensify, so does the pressure from pathogenic bacteria. • Reliance on antibiotic solutions is unsustainable. Demand for effective natural solutions. • The global feed additive market for natural additives is currently € 3 bn and rising. • The need of antibiotic free meat production is consumer driven. “Antimicrobial resistance is one of our most serious health threats” The Lancet 2013 “ Half of the raw chicken meat carried antibiotic-resistant “superbug” bacteria in USA” Reuters 19. 12. 2013 Nature Creates – We Refine

1. Naturally • Rosin, containing resin acids, has been used in traditional medicine in Finland for centuries • The antimicrobial and antiprotozoal effects of resin acids are proven by scientific trials (Ali et al. 2012, Sipponen A. 2013) • We are the first to develop the resin acids into a form that optimizes their efficacy in animal feeding (patents) Nature Creates – We Refine

2 Active: Prog. Res supports the health and productivity of animals • In trials Progres has: • Prevented the growth of pathogenic Gram+ bacteria – Such as clostridium perfringens and streptococcus suis • Reduced the development of necrotis enteritis • Modified the composition of intestinal microflora to beneficial direction • Lead to decreased mortality, better health and growth performance in broilers and turkeys Nature Creates – We Refine

The effect of Prog. Res on the growth of different pathogenic Gram+ bacteria (Alimetrics 2014) Nature Creates – We Refine

NE challenge trial with broiler chicks Alimetrics 2012 • • Wheat –based starter diet without coccidiostat Progres inclusion at 0, 0. 1, 0. 5, 1 and 3 kg/tn 1 -day-old Male Ross 508 broiler chickens 6 chickens/pen, 8 pens/diet Nature Creates – We Refine

Progres® at high dose decreased mortality due to necrotis enteritis Alimetrics 2012 **, p < 0. 01 (H. Kettunen et al. 2015 J. Applied Animal Sci) Nature Creates – We Refine

Challenge trial in broilers at Schothorst Feed Research 2014 • 96 male broilers per treatment (6 *16 birds) • Eimeria maxima challenge at day 9, Clostridium perfringens challenge at day 14 • Progres additions 0, 1, 2 and 3 kg per ton • The challenge caused a sub-clinical infection without affecting mortality Nature Creates – We Refine

Broiler trial at Schothorst Feed Research 2014 Body weight gain g, 9 -35 pv 2300 2200 2190 2100 2000 1900 c 1600 1500 2047 bc bc 2016 a, b p < 0. 05 1875 1800 1700 2070 ab a Healthy Challenged Progres 1 Progres 2 Progres 3 control Nature Creates – We Refine

Scientifically proven efficacy Improves performance Nature Creates – We Refine

Progres® Trials in broilers 2014 CC + feeds Difference in end weight Difference in FCR, g to the control g France UK Denmark + 41 + 32 + 10 +-0 - 60 - 10 The Netherlands + 49 - 20 + 118 + 195 + 226 +-0 +- 0 - 60 CC – feeds France The Netherlands Finland Nature Creates – We Refine

Other potential applications • Trials with calves, piglets, fish and ruminants are going on • Other feed applications (other poultry species, rabbits, sheep, pets etc. ) • Non-feed applications Nature Creates – We Refine

Thank you for your interest! Nature Creates – We Refine