Mutations in the Reverse Transcriptase Gene Associated With

Mutations in the Protease Gene Associated With Resistance to Protease Inhibitors Atazanavir +/-ritonavir Darunavir/

Mutations in the Protease Gene Associated With Resistance to Protease Inhibitors (cont’d) Nelfinavir Saquinavir/

Mutations in the Envelope Gene Associated With Resistance to Entry Inhibitors Enfuvirtide Maraviroc User

Mutations in the Integrase Gene Associated With Resistance to Integrase Strand Transfer Inhibitors Dolutegravir

IAS–USA Drug Resistance Mutations Group 2017 Update of the Drug Resistance Mutations in HIV-1

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Mutations in the Reverse Transcriptase Gene Associated With Resistance to Reverse Transcriptase Inhibitors Nucleoside and Nucleotide Analogue Reverse Transcriptase Inhibitors (n. RTIs) 69 Insertion Complex (affects all n. RTIs currently approved by the US FDA) Multi-n. RTI Resistance 151 Complex (affects all n. RTIs currently approved by the US FDA except tenofovir) Multi-n. RTI Resistance Thymidine Analogue-Associated Mutations (TAMs; affect all n. RTIs currently approved by the US FDA other than emtricitabine and lamivudine) Multi-n. RTI Resistance © 2017. IAS–USA Wensing et al. Top Antivir Med. 2017; 24(4). Updates, user notes, and references available at www. iasusa. org.

Mutations in the Reverse Transcriptase Gene Associated With Resistance to Reverse Transcriptase Inhibitors (cont’d) Abacavir Didanosine Emtricitabine Lamivudine Stavudine Tenofovir Zidovudine © 2017. IAS–USA Wensing et al. Top Antivir Med. 2017; 24(4). Updates, user notes, and references available at www. iasusa. org.

Mutations in the Reverse Transcriptase Gene Associated With Resistance to Reverse Transcriptase Inhibitors (cont’d) Nonnucleoside Analogue Reverse Transcriptase Inhibitors (NNRTIs) Efavirenz Etravirine Nevirapine Rilpivirine © 2017. IAS–USA Wensing et al. Top Antivir Med. 2017; 24(4). Updates, user notes, and references available at www. iasusa. org.

Mutations in the Protease Gene Associated With Resistance to Protease Inhibitors Atazanavir +/-ritonavir Darunavir/ ritonavir Fosamprenavir/ ritonavir Indinavir/ ritonavir Lopinavir/ ritonavir © 2017. IAS–USA Wensing et al. Top Antivir Med. 2017; 24(4). Updates, user notes, and references available at www. iasusa. org.

Mutations in the Protease Gene Associated With Resistance to Protease Inhibitors (cont’d) Nelfinavir Saquinavir/ ritonavir Tipranavir/ ritonavir © 2017. IAS–USA Wensing et al. Top Antivir Med. 2017; 24(4). Updates, user notes, and references available at www. iasusa. org.

Mutations in the Envelope Gene Associated With Resistance to Entry Inhibitors Enfuvirtide Maraviroc User Notes available at www. iasusa. org © 2017. IAS–USA Wensing et al. Top Antivir Med. 2017; 24(4). Updates, user notes, and references available at www. iasusa. org.

Mutations in the Integrase Gene Associated With Resistance to Integrase Strand Transfer Inhibitors Dolutegravir Elvitegravir Raltegravir © 2017. IAS–USA Wensing et al. Top Antivir Med. 2017; 24(4). Updates, user notes, and references available at www. iasusa. org.

IAS–USA Drug Resistance Mutations Group 2017 Update of the Drug Resistance Mutations in HIV-1 Annemarie M. Wensing, MD, Ph. D; Vincent Calvez, MD, Ph. D; Huldrych F. Günthard, MD; Victoria A. Johnson, MD; Roger Paredes, MD, Ph. D; Deenan Pillay, MD, Ph. D; Robert W. Shafer, MD; Douglas D. Richman, MD Top Antivir Med. 24(4). Updates available at www. iasusa. org. IAS–USA is a not-for-profit, HIV clinical specialist–education organization. It is entirely different from and not affiliated with the International AIDS Society. © 2017. IAS–USA Wensing et al. Top Antivir Med. 2017; 24(4). Updates, user notes, and references available at www. iasusa. org.