Mutations 1 Hollywood likes mutations 2 Hollywood likes
- Slides: 33
Mutations 1
Hollywood likes mutations. . 2
Hollywood likes mutations. . 3
X-Men movies and others… 4
Mutations for us can be different than Hollywood Versions… Cancer—skin, liver, lungs, brain… 5
Mutations for us can be different than Hollywood Versions… Cancer—skin, liver, lungs, brain… Lactose intolerant—cannot digest milk/dairy products 6
Mutations for us can be different than Hollywood Versions… Cancer—skin, liver, lungs, brain… Lactose intolerant—cannot digest milk/dairy products Diabetes 7
Mutations for us can be different than Hollywood Versions… Cancer—skin, liver, lungs, brain… Lactose intolerant—cannot digest milk/dairy products Diabetes Shortness in height 8
Mutations for us can be different than Hollywood Versions… Cancer—skin, liver, lungs, brain… Lactose intolerant—cannot digest milk/dairy products Diabetes Shortness in height Shorter life expectancy 9
Mutations for us can be different than Hollywood Versions… Cancer—skin, liver, lungs, brain… Lactose intolerant—cannot digest milk/dairy products Diabetes Shortness in height Shorter life expectancy Others. . . 10
What Are Mutations? Changes in the nucleotide sequence of DNA May occur in somatic cells (aren’t passed to offspring) May occur in gametes (eggs & sperm) and be passed to offspring 11
Are Mutations Helpful or Harmful? Mutations happen regularly Almost all mutations are neutral Chemicals & UV radiation cause mutations Many mutations are repaired by enzymes 12
Are Mutations Helpful or Harmful? Some types of skin cancers and leukemia result from somatic mutations Some mutations may improve an organism’s survival (beneficial) 13
Types of Mutations 14
Chromosome Mutations May Involve: Changing the structure of a chromosome The loss or gain of part of a chromosome 15
Chromosome Mutations Five types exist: Deletion Inversion Translocation Nondisjunction Duplication 16
Deletion Due to breakage A piece of a chromosome is lost 17
Inversion Chromosome segment breaks off Segment flips around backwards Segment reattaches 18
Duplication Occurs when a gene sequence is repeated 19
Translocation Involves two chromosomes that aren’t homologous Part of one chromosome is transferred to another chromosomes 20
Translocation 21
Nondisjunction Failure of chromosomes to separate during meiosis Causes gamete to have too many or too few chromosomes 22
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Chromosome Mutation Animation 24
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Gene Mutations Change in the 26 nucleotide sequence of a gene May only involve a single nucleotide May be due to copying errors, chemicals, viruses, etc.
Types of Gene Mutations Include: Point Mutations Substitutions Insertions Deletions Frameshift 27
Point Mutation Change of a single nucleotide Includes the substitution of ONE nucleotide in a gene 28
Point Mutation Sickle Cell disease is the result of one nucleotide substitution Occurs in the hemoglobin gene 29
Frameshift Mutation Inserting or deleting one or more nucleotides Changes the “reading frame” like changing a sentence Proteins built incorrectly 30
Frameshift Mutation Original: The fat cat ate the wee rat. Frame Shift (“a” added): The fat caa tat eth ewe era t. 31
Amino Acid Sequence Changed 32
Gene Mutation Animation 33
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