Mutant BRafV 600 E Promotes Melanoma Paracellular Transmigration

Mutant B-Raf(V 600 E) Promotes Melanoma Paracellular Transmigration by Inducing Thrombin-mediated Endothelial Junction Breakdown* Pu Zhang, Shan Feng, Gentao Liu, Heyong Wang, Huifeng Zhu, Qiao Ren, Huiyuan Bai, Changliang Fu, Cheng Dong Journal of Biological Chemistry Volume 291 Issue 5 Pages 2087 -2106 (January 2016) DOI: 10. 1074/jbc. M 115. 696419 Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 1. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 2. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 2. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 2. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 3. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 4. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 5. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 5. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 6. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 7. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 8. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 9. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions

FIGURE 10. Journal of Biological Chemistry 2016 2912087 -2106 DOI: (10. 1074/jbc. M 115. 696419) Copyright © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology Terms and Conditions