Multiple testing with SNP data sets SNP Disease

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Multiple testing with SNP data sets SNP ? Disease Test Test_M Combination of SNPs

Multiple testing with SNP data sets SNP ? Disease Test Test_M Combination of SNPs Test Test_1 Test! SNP_28 SNP_100 SNP_16 SNP_3 SNP True False Disease SNP_1 SNP_4 SNP_2 Disease SNP_N -One SNP to one disease Problem : Weak relations between SNP and disease →Missing heritability Disease … Test_n Test_1〜Test_M -Many SNPs to one disease Problem : Too many combinations “How we calculate significance with huge combinations? ” →Overcoming Missing heritability

X 1 = W x H 1 X 2 = W x H 2

X 1 = W x H 1 X 2 = W x H 2 X 3 = W x H 3

dimensio n Cases Contro ls AA Aa aa Type I error

dimensio n Cases Contro ls AA Aa aa Type I error

Integrated analysis of immune phenotype Day 0 Day 1 Mapping Day 7 Day 90

Integrated analysis of immune phenotype Day 0 Day 1 Mapping Day 7 Day 90

Data-driven cell shape analysis of 4 D imaging 4 D live cell imaging 3

Data-driven cell shape analysis of 4 D imaging 4 D live cell imaging 3 D cell shape reconstruction Analysis Spherical parameterization Spherical harmonics decomposition Image Statistical analysis

Statistical Analysis of 3 D Objects by Graph Representation Based on the Curvatures (1)

Statistical Analysis of 3 D Objects by Graph Representation Based on the Curvatures (1) Cell 3 D shapes (2) (3) Graphs (4)

Sets Sets Sets Sets Sets Sets Sets TheSets Sets Sets Sets Sets Sets Sets The
Par SNP Hash Pipeline to parse SNP dataPar SNP Hash Pipeline to parse SNP data
USING SETS IN LINGO What Are Sets SetsUSING SETS IN LINGO What Are Sets Sets
Disjoint Sets Chapter 8 Sets Sets are madeDisjoint Sets Chapter 8 Sets Sets are made
Limit Sets Limit Sets Defined Limit Sets groupsLimit Sets Limit Sets Defined Limit Sets groups
Probability Sets First we will revise sets SetsProbability Sets First we will revise sets Sets
SETS Sets are denoted by Capital letters SetsSETS Sets are denoted by Capital letters Sets
Sets and Probability Sets Sets Set a wellSets and Probability Sets Sets Set a well
Multiple Choice Multiple Choice Multiple Choice Multiple ChoiceMultiple Choice Multiple Choice Multiple Choice Multiple Choice
LD SNP ht SNP A C G TLD SNP ht SNP A C G T
Simulated data sets Extracted from The data setsSimulated data sets Extracted from The data sets