Multiple Scleroris Lyle Wiemerslage Ph D Typical Clinical
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Multiple Scleroris Lyle Wiemerslage, Ph. D
Typical Clinical Vignette • Female in her late 20’s – About twice as common in women – Genetic susceptibility – Geography, more common far from equator • First symptom optic neuritis – Loss of vision OD OS
Molecular Description https: //vimeo. com/68315620
Clinically Isolated Syndrome (CIS) versus MS
Treatments for MS • Interferon α and β – NAbs • Glatiramer acetate – Molecular decoy? • Monoclonal antibodies – Natilizumab – Alemtuzumab – NAbs
Oral Medications • Fingolimod • Teriflunomide • Dimethyl fumarate
Making an animal model for MS + Freund's adjuvant
Clinical Trials for MS • clinicaltrials. gov • Outside of academia
Lifespan of a drug
Preclinical • Basic science – Academic work – Drug discovery – High throughput screening • No Observable Adverse Effect Levels (NOAEL) • Investigator's brochure (IB) – Animal studies – Adverse effects
Finding Effective Treatments • IFN-γ – Thought it may work as antiviral, MS patients also had decreased production of it (false)
Measuing Symptoms • Number of relapses – Placebo effect • MRI • Expanded Disability Status Scale (EDSS) • multiple sclerosis functional composite (MSFC)
Contract Research Organiztion • ”A multicenter, double-blind, randomized, placebo-controlled, parallel group, efficacy and safety trial of *drug* in patients with. . . ”
Economics of Clinical Research • US patent lasts 17 years – Development to approval takes ≈10 years • Research is expensive! – 80. 000 to 400. 000 kr per patient • Orphan drugs • Price of medication can be 400. 000 kr/year/pt
More Information • Curing MS: How Science is Solving the Mysteries of Multiple Sclerosis – Howard Weiner • Blog for clinical research: http: //pipeline. corante. com/
- Masplas
- Pnwvhfs
- James lyle johnson
- James lyle md
- Lyle c may death row
- Brenda andrews oklahoma
- Tyte&lyle
- Lyle alzado cause of death
- Multiple instruction multiple data
- Delayed multiple baseline design
- Typical graph
- Best milk a typical profit-maximizing dairy firm
- Typical school day
- Typical graph
- Typical gd comprises of a small group of candidates
- A typical film