Multiple Myeloma malignant proliferation of plasma cells tumor

Multiple Myeloma • malignant proliferation of plasma cells • tumor, its product, host response --> bone pain or fracture, renal failure, susceptibility to infection, anemia, hypercalcemia, clotting abnormality, neurologic symptoms, hyperviscosity syndrome • rare under 40 year of age, male, black

POEMS syndrome 1. 2. 3. 4. 5. Polyneuropathy Organomegaly Endocrinopathy Monoclonal gammopathy skin change · Medical Emergency: cord compression, pathologic fracture, hyperviscosity, sepsis, hypercalcemia

Ig D 골수종 1) 발생연령이 낮다. 2) 남성이 많다. 3) extramedullary disease가 많다. 4) organomegaly가 많다. 5) total protein의 양이 낮다. 6) M-protein의 peak가 낮거나 없다. 7) lambda형 우위를 보인다. 8) light chain proteinuria, nephropathy가 많다.

Prognostic Factors in Multiple Myeloma • Patient factors: Age P. S. Concomitant illness • • Clinical Stage b 2 M IL-6, LDH, TK PCLI • Morphological factors: plasmoblastic subtypes plasma cell % circulating plasma cell • Cytogenetics, 13 q del • CRP, etc.

Event-free and overall survival times based on serum LDH levels at diagnosis and 13 in a group of 155 newly diagnosed myeloma patients treated with HDT. CA, cytogenetic abnormalities.

Event-free and overall survival times of 515 patients receiving autotransplants and a median follow-up of at least 5 years.

Serum M spike in patients with primary amyloidosis.

Distribution of dominant syndromes in patients with amyloid. GI, gastrointestinal.