MultiCompartment Pharmacokinetics Chapters 19 and 20 http www

Multi-Compartment Pharmacokinetics Chapters 19 and 20 http: //www. boomer. org/c/p 4/

One versus Two Compartment • Rapid Equilibrium versus Slower Equilibrium http: //www. boomer. org/c/p 4/c 1901. html

Multi-Compartment Pharmacokinetic Model • • Deviation from One Compartment Models and Parameters Equations Parameter Estimation Effect of Changing Parameters Apparent Volumes of Distribution Dosage Calculations Oral Administration

Multi-Compartment Pharmacokinetic Model

This Equation is A. The integrated equation for concentration after an IV bolus B. The differential equation for concentration after an IV bolus C. The integrated equation for concentration after an oral dose

A Two Compartment Model becomes One when A. k 12 and k 21 are fast B. k 21 is faster than k 12 C. CLD is fast D. All of the above

Varea is Calculated using A. The dose and the intercept values (A and B) B. The dose, AUC and beta C. V 1 and the microconstants

Achieving and maintaining a specified Cp is easier with a 2 C drug A. True B. False

Non Compartmental Analysis • • Linear (First-order) Kinetics No Model ‘Requirement’ New Parameters – AUMC, MRT, MAT Faster Calculation with Spreadsheet or SAS

Non Compartmental Analysis

The mean residence time can be calculated as A. B. C. D. AUMC/AUC AUC/AUMC 2 Dose/AUC

An estimate of ka can be calculated from A. B. C. D. AUC AUMC MRT MAT

Do you usually have your laptop AND phone connected to Wi. Fi in this room? A. True B. False

Have you had problems connecting to the Wi. Fi in this room? A. Never B. Occasionally C. Often

Have you had problems connecting to the Wi. Fi in this room during in-class Quiz or Exams A. True B. False