Mouse Genetics for Complex Trait Research Lines Represented

Mouse Genetics for Complex Trait Research Lines Represented in Established Genetic Resources: • BXD RI lines • Collaborative Cross • Northport Cross Fleet 2016

Common Mouse Genetic Resources + Genetic Diversity Increases as the Number of Inbred Lines in the Cross Increases Roberts et al. 2007 Mammal Genome 18: 473

The Collaborative Cross (available from UNC-Chapel Hill) Ambitious project designed to generate 1000 Recombinant Inbred (RI) Mouse lines. The actual number is currently closer to 100 lines. Threadgill et al. (2014) ILAR J 52: 24

Mouse Resources for Genetic Association

The Diversity Outbred Cross (available from JAX) https: //www. jax. org/strain/009376 DO mice are bred by JAX to maintain genetic diversity Each mouse is a mosaic of genetic material from 8 inbred mouse lines These 8 lines are the same ones used by the Collaborative Cross.

Eight Inbred Lines A/J, AKR/J, BALB/c. J, C 3 H/He. J, C 57 BL/6 J, CBA/J, DBA/2 J and LP/J Heterogeneous Stock Mice (Welcome Trust) Breed for maximal diversity Maximize Recombination http: //mus. well. ox. ac. uk/mouse/HS/#genotypes Use for GWAS Genotypes and Phenotypes are available at this website These mice are not available.

Hybrid Mouse Diversity Panel https: //systems. genetics. ucla. edu/ Data from more than 100 inbred and RI lines. (Each can be purchased at JAX) Used for Association Mapping of traits to genetics Multiple phenotypes available Genotypes available Other mouse genetic data available too. Aldon “Jake” Lusis’ Research group

Mouse Genetic and Phenotype Databases Bioinformatic Resources Morgan and Welsh (2015) Mammalian Genome 26: 521

The Gene. Network (Web. QTL) http: //www. genenetwork. org/webqtl/main. py Groups (Genetic Models) Types of Data Includes F 2 populations Recombinant Inbred Lines and the HS Stock

The Jackson Labs (JAX) https: //www. jax. org/ JAX also has a huge collection of inbred, transgenic, and knockout mice. http: //www. informatics. jax. org/ http: //phenome. jax. org/

More JAX Resources http: //cgd. jax. org/tools. shtml

http: //compgen. unc. edu/wp/? page_id=135 Home of the Collaborative Cross http: //msub. csbio. unc. edu/

Mutant Mouse Databases

Chemically Induced Mutagenesis of Mouse

Knockout Mouse Consortia http: //www. mousephenotype. org/