MOTIC VM 600 Virtual Microscope Development of Motics

MOTIC VM 600 Virtual Microscope Development of Motic’s New Model; Features & Improvements, Model Strategy, and Model Competition Motic International Dealer Meeting March 2009

Topics Covered 1. Motic VM Introduction: Hardware & Softwares 2. Application solutions: a. Clinical Diagnosis/ b. Consultation, Research c. Education 3. VM System Operation & software 4. Competitive Analysis

Motic Products Solution www. moticpathology. co m VM 600 -4：Digital Slide Scanner 1、DPCC（ Digital Pathology Consultation & Communication Platform ） www. motic. com/dssweb 2、DSS（ Digital Slide Server System ） VM：Digital Slide View software

Motic VM Components (Hardware & Scanning software)) 4

Scanning Process Demo： Scanning

Digital Slide View Demo

Motic Pro 285 CCD 1. Motic 285 A： 2/3 " , 1360 x 1024, 6. 45 m x 6. 45 m MCAM 285 Technical Data 　Item Sensor Size MCAM 285 2/3"CCD Resolution 1. 4 mega pixels, 1360 X 1024 pixels Pixel Size 6. 45 m x 6. 45 m Frame Rate 15 fps / second Shutter Electronic Dynamic Range >44 db S/N Scanning System Progressive Minimum Illumination USB Interface Voltage Operating Current Power Consumption ≈3 Lux USB 2. 0(480 Mbit/sec DC 5 V± 5% ≈260 m. A ≈1. 3 W Operating Temperature 0℃-50℃ Storage Temperature 0℃-60℃ Relative Humidity 40%-80% OS recommended WINDOWS 2000 / WINXP / VISTA

Scanning Speed Objective: 20 x； Specimen： 10 mmx 10 mm； Scanning Method: Standard； Speed：About 4 min

VM 600 Stage Configuration • X - 272 mm；Y - 196 mm；Z - 93 mm ; • Travel range of 80 mm by 24 mm • Stage Accuracy: 1. 5625 um for x/y –axis, ; 0. 015 um for z-axis; • Relocation Accuracy: <1 um

Motic VM 600 Recommended PC Specifications Workstation System: • Windows XP Professional • Intel Core(TM) 2 processors • 4 GB RAM • 300 GB disk storage • 22 “ Monitor(or larger Optional)

Motic VM Scanning Methodology 1. High Precision Auto –Focus every Image , high quality 2. Standard ： Build Scanning model , good quality with faster scanning speeds 3. ROI（Region of Interest）: Scan whole slide with low magnification(2 x or 4 x) first, then scan ROI with higher magnification. Small Digital slide Size(<10 M), useful and convenient for pathology or educational applications (Motic only feature) 4. Multilayer Focus: Multilayer focus and amalgamation each tiled image. Very high quality , especially for thick glass slide (but may be too slow for most applications)

Multilayer Focus Scanning

Multi-Layer Amalgamation

Traditional Pathology Workflow Surgery Center Pathology Center Living specimen Freezes Tissue specimen Pathology Education Fix, Dehydrate, Embedding…. Histoprocessing Slide Staining Pathology Diagnosis Pathologist Center Slides

Digital Pathology Solution: Adjusting Standard Workflows Surgery Center Pathology Center Living specimen Freezes Tissue specimen Fix, Dehydrate, Embedding…. Histoprocessing Slide Staining Education Image Analysis Workflow Management Pathology Diagnosis &Analysis Remote-Consultation Digital Slides Pathologist Center Slide

Future Digital Pathology Directions • Information Workflow, including Digital Slides… • Integrated Patient records (HIS/PACS…) • Education & Clinical • Remote-Consultation • Image analysis

MOTIC’s Digital Development Makes the VM 600 The Next Logical Progression … Microscope Micro+Camera Digital Pathology

VM Application Solutions

VM 600 Digital Slide Applications v v Educational (Cell Morphology, Histology, Pathology, etc. ) Digital Slides Classroom Teaching Remote Teaching and Learning Virtual (Web) Teaching Lab for Images view and conference v v v Clinical Diagnosis(Pathology) Digital Images Data and workflow Management Remote Consultation Digital Slides Conference Aided Diagnosis v v v Research Digital Slides Data TMA Image analysis Pharmaceuticals

VM Educational Applications

Digital slides Education System for Pathology and Histology Teaching ØClassroom Teaching 1. Digital Slides reduce concerns about slide making, loss, breakage or fading; 2. Archive and share critical slides; 3. Built-in Digital Slide information management to reduce teacher prep time for course development and dedicate more time to viewing ØDigital slides Testing 1. Manage digital slides to create a test library as an effective means for distributing testing materials; 2. Auto testing ØDigital Slides gallery( Web view) 1. Anywhere , anytime access via internet on web, Prelearning and Review ; 2. Improving the teaching level and learning effectively;

Motic Digital Slides Server Software System(DSS) System l. Lan/Internet IE View DSS Server Web-Based IE View Motic VM workstation

Motic Digital Slides Server System(DSS) System Web-Based View by annotation , convenient for teaching and learning

Incorporating VM 600 with Motic Net as an effective teaching tool. . Education (VM 600 with Motic Net)

For Pathology Diagnosis (Secondary) & Consultation

Motic VM Feature: Observe slide by Motic VM whiling or after scanning the slide , it is the best way for beginning of diagnosing training

Digital Pathology Consultation & digital slide Communication Platform Remote Experts DPCC Platform LAN or Internet （ADSL） Motic VM Remote Consultation Center Consultation station On business or at home

Motic DPCC Platform Web Address http: //www. moticpathology. com

Digital Pathology Information Workflow Motic VM HIS Patie t en nt Info rmatio an M nfo n m ge a I C DI PIS OM Digital Slides Work flow Remote Consultation Conference Internet) Report

Competitive Analysis

Market Sector Competitors 1. Zeiss Mirax 2. Olympus Bliss HD or. slide 3. Aperio 4. Hamamatsu NDP 5. Nikon Coolscope 6. Claro 7. DMetrix ……

Zeiss Mirax DESK(1 -slide) Mirax MIDI(12 -slide) Mirax SCAN(300 -slide) Objective: Plan-Apochromat 20 x/0. 8 Scan camera: SONY DFW-X 710 or others (1/3“inch, 1024 x 768 pixels, cell size 4. 65 x 4. 65 µm )

Zeiss (3 DHISTECH, Hungarian company) MIRAX Viewer - the virtual microscope MIRAX MFM - fluorescent slide viewer MIRAX TMA - a powerful tool for high throughput tissue microarray evaluation IH-Lab - software for fast evaluation of immunohistochemistry stained samples Histo. Quant - quantitative and qualitative analysis application MIRAX E-School - teaching material authoring tool with exam module MIRAX 3 D - an application for 3 -dimensional reconstruction of serial slides E-Consult – teleconsultation software MIRAX DB - database program for efficient data management Toxico. Path-LIS - application for the management and administration of toxicopathology research

Olympus Dot slide(1 -slide/50 -slide) Objectives : 2 x PLAPON, 10 x, 20 x, 40 x UPLSAPO, optional, e. g. 100 x oil Illumination: brightfield with 100 W halogen lamp house, optional: fluorescence, polarisation Digital CCD camera: 2/3” CCD camera, 6. 45 μm x 6. 45 μm pixel size Software functions and modules. View images locally, zoom, crop and rotate images. Net Image Server software for remote access to virtual slides with dot. Slide software. Conferencing module for simultaneous and synchronised viewing of virtual slides, conference access control and user management, minute taking tool, chat function. TMA module to acquire individual images of TMA cores Bacus: Bacus Laboratories, inc. , a whollyowned subsidiary of Olympus America. Founded in 1994, is a leader and innovator in the field of VM.

Hamamastu NDP: 210 -slide Objective lens: 20 X, NA 0. 7 CCD: TDI sensor, 4096 x 64 pixel , Line scanning Software: Developed by other company Distributed now in the USA through the Olympus network, approx cost $120 K

Aperio 120 -slide 1 -slide 5 -slide 1 -slide(Oil) Objective lens: PLAN-APO 20 x / 0. 75 CCD: Line 3 -CCD, 1040 x 1 pixel

Nikon Cool. Scope CCD: 2/3 -inch. (total number of pixels: 5. 24 -mega pixels; effective 5. 07 -mega pixels)

Dmetrix . Objective : Array Micro lens (80). The fastest scanning system

Claro(Japan) Toco: 1 -slide VS 0201 AS 1 : 20 -slide VS 0801 AS 1: 80 -slide Objective: Carl Zeiss Aplan 20 x, 40 x Camera: 1/2 CMOS (1280 x 1024) or 1/2 IT CCD' (1280 x 960)

Clarient/Trestle/Dako Clarient: formed in 1996 to develop and market the ACIS(R) Automated Cellular Imaging System, in cancer diagnostics Sells Its ACIS Instrument Business to Carl Zeiss for $12. 5 Million Following the acquisition of Trestle and of Clarient's equipment business, Carl Zeiss has become the leading provider of solutions for telepathology, digital slides and computer- supported diagnostics with more than 500 installed systems. In marketing a clinical version of the system, Carl Zeiss Micro. Imaging said it is collaborating with the Danish diagnostics company Dako, a manufacturer of reagents for tissue-based cancer diagnosis.

Motic’s Strategic Positioning: 1. Natural Digital progression for Motic into Virtual slide making market 2. Offer “single-source” complete and easy integrated with VM hardware and software 3. 4. Package Applications by combining VM Digital slide with Motic Net 5. Highest Resolution Sony CCD 6. Different scanning methods; ROI slide for remote consultation 7. Value-Alternative to customer Motic: Value-Based alternative to easy and efficient digital slide creation and integration!