Molecular Imprinting Polymers MIPs Introduction q In chemistry

Molecular Imprinting Polymers MIPs

ØIntroduction q In chemistry, molecular imprinting is a technique to create template-shaped cavities in polymer matrices with memory of the template molecules.

Schematic of molecular imprinting a c assembly Template (binding) b 1 - add cross-linker 2 - polymerise (in porogenic solvent) template removal re-binding recognition site Template

ØHistory of Molecular Imprinting q Molecular imprinting was used as early as the 1930's by MV Polyakov to selectively capture various additives in a silica matrix. q In the 1940's Linus Pauling hypothesized that a process similar to molecular imprinting could be responsible for the selectivity of antibodies to their respective antigens.

ØBiological systems q Molecular recognition plays an important role in biological systems and is observed in between receptorligand, antigen-antibody, DNA-protein, sugar-lectin, RNA -ribosome, etc Antigens Antigen-binding site Antigen

ØHistory of Molecular Imprinting q The concept of molecular imprinting was revived in the 1970's when Günter Wulff discovered that highly crosslinked organic polymers could also be used to make molecular imprints with high specificity. q In more recent years, imprinted polymers have been used to capture everything from steroids to TNT.

ØImprinting methodologies Covalent Reversible covalent linkage

ØMolecular Imprinting: Covalent Wulff & Schauhoff J. Org. Chem. , 1991, 56, 395 -400.

ØImprinting methodologies advantages and disadvantages Covalent Imprinting l Ability to fix template in place during polymerisation - lower dispersity in binding sites l Can be carried out in any solvent flexibility l Can be difficult to remove template from polymer - low recovery of valuable templates and low number of binding sites l Limited number of chemistries for fixing template to polymer reversibly - reduction in number of templates that can be imprinted l Poor kinetics of re-binding

ØImprinting methodologies Non-covalent Monomer-template complexes

ØMolecular Imprinting: Non-covalent

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