Molecular Imaging System Upgrade Hardware System Capabilities System

Molecular Imaging System Upgrade: Hardware System Capabilities • • System Capabilities Variables focal lengths Variables projection size Capable of accepting multiple types of lenses – Existing adjustable lens (Camera Lens W/ short focal length) – Thin lens • Able to accept multiple grids – Printed – 12, 20, 30 Line pair per mm Optigrids • Dependent on dimensions & drawing availability from Qioptiq • Fine and course optics adjustments

# Part Description Quantity Vendor Part # Price 99. 75 1 Carestream Box 1 Carestream 2 Opti. Grid 1 Qi. Optiq 3 Dovetail Optical Rail 1 Edmund Optics NT 54 -401 4 Opti. Grid Holder 1 Qi. Optiq 374352 -000 5 Three-Screw Ring Mounts 95 mm Adjustable Len Mount 12. 5 -76 mm 1 Edmund Optics NT 36 -605 49. 00 6 Small Carrier . 5" Dovetail Carrier 2 Edmund Optics NT 54 -403 55. 00 7 Medium Carrier 50 mm Dovetail Carrier w/ M 16 for Lens 1 Edmund Optics NT 55 -341 69. 00 8 Metric Rotary Stage 60 mm 360 Rotary Stage 1 Edmund Optics NT 55 -030 165. 00 9 M 16 x 1. 0 25 mm rod Mount rotary stage to carrier & ring mount 2 10 Thread-to-thread Adaptor M 16 x 1. 0 female to 1/4 -20 male for rotary 1 Edmund Optics NT 55 -208 8. 95 11 1/4 -20 Screws To screw into rails for mounting grid & light 12 1/16" Black Polyurethane 80 A Durometer, 6" x 6" 1 Mc. Master 8716 K 153 11. 74 13 Loctite 404 Quick Set (46551) rubber adhesive, 1/3 oz bottle 1 Ellsworth 46551 17. 69 14 Rule printed sticker 12" ruled tape 1 Mc. Master 15 Camera Lens High Resolution Large Formaat Lens 1 Edmund Optics 16 Micro Rotary Stage . 75" Rotary Stage 1 Edmund Optics NT 56 -572 17 Aluminum Stock 18 Fiber Optic Light Source Goose Neck 1 19 Grid Transparency 1 Output City - 20 Linear Stage 2 Edmund Optics NT 56 -357 12" Optical Rail Optional for moving printed transparency >20 1000. 00 260. 00 210. 00

Optical System Diagram

Molecular Imaging System Upgrade: Software System Capabilities • Consist of three separate programs • Kodak Molecular Imaging Software • Optigrid Motor Control GUI • MATLAB – Scripts will be developed as necessary for calibration and depth resolved discrimination • Optigrid Calibration – A system specific calibration process will be developed – Process will rely on manual coordination of three separate programs • Implement necessary algorithms to achieve depth discrimination, as described by Tromberg et al. in US Publication 2006/0184043

Optigrid Calibration Camera Parameters Gain Offset Grid Optimization Determine Linearity Merit Function Phase vs. Voltage Full System Verification Camera Software Frequency Analysis (MATLAB, EXCEL) Optigrid Required

Depth Discrimination • Fourier transform – filtering – inverse Fourier transform • Involves using calibration reference to determine optical properties

Deliverables for Detailed Design Review • Outlined step by step process for Optigrid calibration – Including prefabricated scripts from Qioptiq – Needs to be system specific – Status: Near complete. Require input from Qioptiq • Algorithm “pseudo-code” documenting mathematical theory and envisioned procedure for implementation – Status: Preliminary document in place. To be reviewed with customer before design review