Molecular Axon Guidance PC 12 cell then NGF
- Slides: 32
Molecular Axon Guidance PC 12 cell…. then NGF added NGF is neurotropic and neurotrophic
Guidance Factors Growth Factors
Netrin. . was one of the first neurotropic factors
Findings
Netrin from FP
Netrin from FP, But perpendicular
Netrin in media
Cell locomotion like GCs Cell moves forward by extending filipodia & lamellipodia Focal adhesions are formed Cell is pulled forward
Diffusible Contact dependent
Extracellular matrix
Extracellular matrix Proteins of ECM - collagen
Extracellular matrix Proteins of ECM - proteoglycans
Extracellular matrix Proteins of ECM - fibronectin
Extracellular matrix collagen Proteins of ECM - laminin
Interaction of cells with ECM INTEGRINS inactive
Interaction of cells with ECM INTEGRINS ligands have RGD motif differentiation motility growth survival functions of outside-in signals
Interaction of cells with ECM FOCAL ADHESIONS FA
Interaction of cells with ECM FOCAL ADHESION S
Interaction of cells with cells CELL ADHESION MOLECULES
Interaction of cells with ECM and other cells CELL ADHESION MOLECULES VS ECM ATTACHMENT MOLECULES
Ca 2+ Wnt E-Cadherin Frz II -catenin P p 120 -catenin APC Dsh Axin actin filaments Gsk 3 P Tcf/Lef Extracellular Space
Cadherins as Master Regulators of Morphology • Focus is often on adhesive function: Cadherins as molecular glue AJ’s Type of Cadherin Stabilize others junctions Adhesion Passive Inhibition Rho-GTPases Active Promoter Motility CDKI: p 27/p 21 Wnt Proliferation Cadherins Receptor Signaling EGF FGF PDGF Actin Cytoskeleton Transcriptional/ Nuclear Role -catenin/Wnt P 120/kaiso In nucleus -catenin Rho-GTPases Arp 2/3
- Ngf plumbing
- Cross tooth cross arch balance
- Indirect and direct guidance
- Melting and boiling point of oxygen
- Ionic covalent metallic
- Giant molecular structure vs simple molecular structure
- Nociceptor stimulus
- Nerve impulse
- Integrating sensory input with motor output
- Degeneracion walleriana
- Axon terminus
- Axon hillock
- Axon hillock
- Single cell
- Function of multipolar neuron
- Poliendrica
- Partes de la neurona
- Fissures of the skull
- Nucleus of neurolemmocyte
- Axon patch clamp amplifier
- Axon branches
- Axon
- Axon
- What is the chemoaffinity hypothesis
- Axon dendrite
- Axon
- Neuron type
- "axon"
- Axon outsourcing
- "axon"
- "axon"
- Velőshüvelyes axon
- Axon officer safety plan