Mitglied der HelmholtzGemeinschaft SINE 2020 Chemical Deuteration WP

Tasks Ø Novel route for isoprene synthesis (D 5. 3, month 15) Ø Synthesis

Novel route for isoprene synthesis Ø accessibility/costs of starting compounds Ø monomer purity Ø

Synthesis of deuterium labelled polythiophene based block copolymers 1. GRIM Polymerization of P 3

Synthesis of deuterium labelled polythiophene based block copolymers 2. Diblocks Ø P 3 HT:

Synthesis of deuterium labelled polylactic acid • lactic acid (h and d): ESS •

Synthesis of deuterium labelled polylactic acid Lactide synthesis • D-lactic acid (h), 10 g

Synthesis of deuterium labelled polylactic acid • Conversion to lactide • Purification by sublimation,

Synthesis of deuterium labelled polylactic acid • Polymerization (Dr. Beckerle, RWTH) [Zn. Et 2]/[Bn.

PEG 1. Polymerization of EO (h and d) 2. End group functionalization 10 November

PEG Synthesis of maleimide functionalized PEGs 10 November 2020 Folie 11

Slides: 11

Download presentation

Mitglied der Helmholtz-Gemeinschaft SINE 2020 – Chemical Deuteration WP FZJ Contributions Jürgen Allgaier Jülich Centre for Neutron Science JCNS and Institute for Complex Systems ICS Forschungszentrum Jülich Gmb. H

Tasks Ø Novel route for isoprene synthesis (D 5. 3, month 15) Ø Synthesis of deuterium labelled polythiophene based block copolymers (D 5. 5, month 20) Ø Synthesis of deuterium labelled polylactic acid (D 5. 8, month 30) (Synthesis of L- and D-lactic acid, ESS deliverable D 5. 4) Ø (PEG/PEGylated lipids, D 5. 11) 10 November 2020 Folie 2

Novel route for isoprene synthesis Ø accessibility/costs of starting compounds Ø monomer purity Ø deuteration degree 10 November 2020 Folie 3

Synthesis of deuterium labelled polythiophene based block copolymers 1. GRIM Polymerization of P 3 HT 10 November 2020 Folie 4

Synthesis of deuterium labelled polythiophene based block copolymers 2. Diblocks Ø P 3 HT: structural quality, chemical functionalization Ø impurities: homopolymers, salts Ø deuteration scenarios 10 November 2020 Folie 5

Synthesis of deuterium labelled polylactic acid • lactic acid (h and d): ESS • lactide: FZJ • poly(lactic acid): RWTH (Prof. Okuda) 10 November 2020 Folie 6

Synthesis of deuterium labelled polylactic acid Lactide synthesis • D-lactic acid (h), 10 g - LA 52% LA, 48% open dimer 28% water open dimer, 1 H 10 November 2020 Folie 7

Synthesis of deuterium labelled polylactic acid • Conversion to lactide • Purification by sublimation, recrystallization: (yield: 2 g, 35%) lactide open dimer, 1 H LA 10 November 2020 Folie 8

Synthesis of deuterium labelled polylactic acid • Polymerization (Dr. Beckerle, RWTH) [Zn. Et 2]/[Bn. OH]/[L-Lactide] 1 / 2 / 100 THF; 18 h; ambient temperature 96 % conversion (NMR) 13 C{1 H}NMR Mn D GPC (RI) 10 800 1. 15 Corrected 6 300 - Calculated 6 900 - iii iis/ isi sii 10 November 2020 Folie 9

PEG 1. Polymerization of EO (h and d) 2. End group functionalization 10 November 2020 Folie 10

PEG Synthesis of maleimide functionalized PEGs 10 November 2020 Folie 11