MISFOLDING PROTEIN DISEASE SUMMARY Prion structure and function
- Slides: 65
MISFOLDING PROTEIN ＆DISEASE SUMMARY ü Prion : structure and function ü Prion 的致病機制: Pr. PC→Pr. PSC→Disease ü Misfolding protein 的修正 ü Disease: Kuru, CJD, Parkinson, AD ü 疾病的檢查
Prion : structure and function
C Pr. P SC Pr. P
Misfolding protein 的修正
正常人體該如何排解 misfolded protein？
Disease
Distribution of infectivity in the human body Infectivity category Tissues, secretions, and excretions High infectivity Brain, spinal cord, eye Low infectivity CSF, kidney, liver, lung, lymph node/spleen, placenta No detectable infectivity Adipose tissue, adrenal gland, gingival tissue, heart muscle, intestine, peripheral nerve, prostate, skeletal muscle, testis, thyroid, tears, nasal mucous, saliva, sweat, serous exudate, milk, semen, urine, feces, blood Data based on primates inoculated with CJD tissues and naturally occurring animal TSEs (WHO, 2000)
KURU
Histological features of TSE kuru Scrapie v. CJD BSE
Degenerative diseases n n Parkinson Disease 巴金 森症 Huntington’s Disease 漢丁頓式病 Amyotrophic Lateral Sclerosis (ALS) 肌萎縮 側索硬化症 Alzheimer Disease (AD) 阿滋海默症 Huntington’s disease (caudate nucleus and frontal cortex)
Alzheimer disease 不正常 正常
Parkinson Disease Gross Depigmentation of the substantia nigra in PD (left). Normal sustantia nigra (right)
腦電波出現週期性棘波(periodic sharp wave pattern) 70%會出現此症狀
磁共振成像 枕核丘腦(the pulvinar nuclei of the thalamus) 出現對稱性的高信號
Spike protein prion
Q
Communicable disease and non communicable disease
Protein pump vs protein channel
Protein-protein docking
Deficiency disease of protein
Primary secondary and tertiary protein structure
Primary secondary and tertiary protein structure
Primary secondary and tertiary structure of protein
Protein definition
Nivedita patnaik
Protein function
Protein function
Protein function
Protein function
Protein function
Biological function of protein
Function of plasma protein
Koji tsuda
Hbv protein function in the body
Fibrous protein example
Super secondary structure of protein
Fibroin secondary structure
Super secondary structure of protein
Protein primary structure
Myoglobin primary structure
Carbonbased molecules found
Francis crick
วสท.
Quaternary structure of protein
Protein tertiary structure bonds
Protein structure
Hierarchy of protein structure
Protein structure determination
64 amino acids
Beta meander motif
Super secondary structure of protein
Functions and importance of proteins
Amino acid structures
Leucine polar or nonpolar
Secondary protein structure
Secondary structure protein
Rna secondary structure prediction
Protein structure
Protein structure
Structure and function of community
State vs path function
One one function and onto function
What is function prototype
Brain structure and function
Bean seed labeled parts
Chloroplast function
Anaerobic glycolysis in red blood cells
Function of vacuole
Protist structure and function
Lysosome function
Structure of ferns
Structure and function of cytoskeleton
Breast structure and function
Chapter 10 body structure and function
What are cells made up of
Cytoplasm function in plant cell
Rough endoplasmic reticulum function
Function of amygdala in limbic system
Brain structure and function
What is part 2
