MindBody Connection for Healthy Aging Leon Lenchik MD
Mind-Body Connection for Healthy Aging Leon Lenchik, MD
The Big Picture
What is healthy aging?
What is healthy aging? Not just adding years to life, but adding life to years
Ferrucci L, et al. Circ Res. 2018; 123: 740 -744
Ferrucci L, et al. Circ Res. 2018; 123: 740 -744
Ferrucci L, et al. Circ Res. 2018; 123: 740 -744
Aging Trajectories Healthy Not-so Healthy Partridge L, et al. Nature. 2018; 561(7721): 45
What is healthy aging for you? Please fill in the blank_________
What is healthy aging for me? Preserved physical function Preserved cognitive function Preserved social connections
Healthy Aging Brain Health o Memory o Cognition o Emotional balance Body (non-brain) Health o Physical fitness o Strength, endurance, balance Social Health o Family o Friends o Colleagues
The Details
Mind-Body Connection Basic science Population science Imaging science
Mind-Body Connection Basic science Population science Imaging science
Mind-Body Connection Basic science Population science Imaging science
This positive association between sarcopenia and poor cognition is independent of confounders such as age, sex, depression, education level, physical performance, and common comorbidities
Mind-Body Connection Basic science Population science Imaging science
Our Research on Muscle, Fat, Bone with CT 1. 2. 3. 4. 5. Validation CT vs Mortality CT vs Physical function CT vs DXA CT vs Different CT CT vs Phantoms Automation Ground Truth • Chest/Abdomen Automated Segmentation • Atlas-based • Machine learning-based Beyond CT • PET/CT • MRI Beyond segmentation • Texture/Radiomics Application Observational studies • NLST • DHS • NASA RCTs • HOPE • UPLIFT • BEAT-AD • Panc Ca (EA 2186) Pragmatic • Medicare • UC Davis
Lenchik L, et al. American Geriatrics Society, 2019
Body Composition in T 2 Diabetes
Diabetes Heart Study
Body Composition and Alzheimer’s Disease (AD) • Overweight and obesity are associated with adverse changes in brain structure and function and a 2 to 3 x risk for AD • Aging is associated with fat redistribution and dysfunction, which may explain the associations • Increased ectopic fat (e. g. , VAT and IMAT) is strongly linked to metabolic disease • Adipokines (e. g. , adiponectin) are associated with cognitive decline and dementia • Fat distribution and function are important risk factors for AD
Brain Energy for Amyloid Transformation in AD (BEAT-AD) Study Aim: Determine the association between VAT/SAT ratio and brain amyloid deposition Hypothesis: Higher VAT/SAT ratio will be associated with greater prevalence and severity of brain amyloid deposition (based on 11 C-Pi. B uptake on PET scans at baseline)
Imaging Research Helps understand mind-body connection Mostly done by neuroimaging researchers
Control Exercise and Brain Connectivity
Exercise increases size of hippocampus and improves memory Stretch Exercise Erickson et al, Proc Natl Acad Sci. 2011; 108(7): 3017 -22.
Imaging Research May eventually change clinical practice CT screening for adiposity/sarcopenia may improve physical health and cognitive health
Mind-Body Connection for Healthy Aging What can you do about it now? Leon Lenchik, MD
Leveraging Mind-Body Connection for Healthy Aging Leon Lenchik, MD
Remember the Big Picture
Healthy Aging Interventions Brain Health o Memory o Cognition o Emotional balance Body (non-brain) Health o Physical fitness o Strength, endurance, balance Diet and exercise Social Health o Family o Friends o Colleagues Meetings
Social Health
Social Health
Kritchevsky SB. RCCN Meeting, December 2018
My Big Picture
Positive psychology rules!
The Science of Happiness The first MOOC to teach positive psychology. Learn science-based principles and practices for a happy, meaningful life. https: //www. edx. org/course/sciencehappiness-uc-berkeleyx
It’s not about the money
It’s about relationships
It’s about relationships
MAKEOVER Study (n=1) Meditate Exercise Volunteer Read
This makeover’s not working for you
Remember the Details
Peterson J. RCCN Meeting, December 2018
Peterson J. RCCN Meeting, December 2018
Peterson J. RCCN Meeting, December 2018
Peterson J. RCCN Meeting, December 2018
My Details
Retraining my thoughts
Retraining my thoughts at work Retraining other people’s thoughts
Radiology Faculty Development Update March 2019 Leon Lenchik, MD How do you think about your work?
How do you think about your work? job…. career…. calling
How do you think about your work? job satisfaction job…. career…. calling
How do you think about your work? job…. career…. calling
Nay sayers “I am not a _____” “I just want to read films” “I’m overworked and underpaid” “This is insulting to me”
Intervention #1 Who are you really?
Intervention #2 Fake it till you make it https: //www. ted. com/talks/amy_cuddy_your_body_language_shapes_who_you_are
Intervention #3 Fill in the blank _____
What is healthy aging?
Point of view matters Patient vs doctor
Good News: We’re not just doctors, but patients too So let’s not forget to diagnose and treat our own bodies and minds
Thank You llenchik@wakehealth. edu
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