Migraine Heidi Kaspersen and Martine Sakariassen What is

Migraine Heidi Kaspersen and Martine Sakariassen

What is migraine? • Chronic disorder • Recurrent attacks of headache • Complex neurobiological disorder • Core features: Headache, nausea, light and sound sensitivity etc. • Migraine predisposition varies individually

Phases of migraine

Pathophysiology of migraine • Several theories trying to explain the etiology of migraine • The most accepted ones are the vascular and neurovascular theories

Neurovascular theory Cortical depression spreding (CDS) - Reduction in brain electrical activity and decrease blood flow - Release of K+ and H+ activates sensory fibers - Activation of trigeminal & brain stem neurons - Precipitation of vasodilation

Genetic component • Strong familial influence proved in twinstudies • Mutations in voltage gated calcium channels seen in many families, predisposing to migraine • Related to serotonin release in midbrain

Migraine and neuropsychiatric disorders • Comorbid disorders, such as depression, anxiety, panic disorder and bipolar disorder. • There are several researches and theories explaining the associations.

Migraineurs VS non-migraineurs

Treatment • Pharmacological and non-pharmacological approaches • Pharmalogical: NSAIDs (Aspirin, Ketoprofen), Erogot alkaloids, Triptans • Non-pharmacological: Cold packs to the head, Riboflavin and Magnesium • Medication of prevention: - 1 st line: Propanolol, Amitriptylin - 2 nd line: Valproat, Pisotifen

Sources http: //www. americanheadachesociety. org/assets/1/7/NAP_for_Web__Pathophysiology_of_Migraine. pdf http: //www. medical-hypotheses. com/article/S 0306 -9877(11)00067 -3/abstract http: //link. springer. com/article/10. 1007%2 Fs 11920 -005 -0039 -y#/page-1 http: //nhi. no/foreldre-og-barn/ungdom/sykdommer/migrene-oversikt-2443. html? page=3 http: //nhi. no/foreldre-og-barn/ungdom/sykdommer/migrene-oversikt-2443. html http: //www. psychiatrictimes. com/bipolar-disorder/are-migraines-and-bipolar-disorderrelated-0