Microsatellite instability induced mutations in DNA repair genes

Microsatellite instability induced mutations in DNA repair genes Ct. IP and MRE 11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies by Terry J. Gaymes, Azim M. Mohamedali, Miranda Patterson, Nazia Matto, Alexander Smith, Austin Kulasekararaj, Rajani Chelliah, Nicola Curtin, Farzin Farzaneh, Sydney Shall, and Ghulam J. Mufti haematol Volume 98(9): 1397 -1406 September 4, 2013 © 2013 by Ferrata Storti Foundation

Fluorescent fragment PCR and sanger sequencing of DNA repair gene coding region microsatellites. Terry J. Gaymes et al. Haematologica 2013; 98: 1397 -1406 © 2013 by Ferrata Storti Foundation

Correlation of MSI and HR competency in MDS/AML cell lines and AML patients. Terry J. Gaymes et al. Haematologica 2013; 98: 1397 -1406 © 2013 by Ferrata Storti Foundation

Correlation of MSI positivity and chromosomal instability in MDS patients. Terry J. Gaymes et al. Haematologica 2013; 98: 1397 -1406 © 2013 by Ferrata Storti Foundation

Identification of MSI positivity in patients with high risk MDS. (A). Terry J. Gaymes et al. Haematologica 2013; 98: 1397 -1406 © 2013 by Ferrata Storti Foundation

HR responses after modulation of the MMR pathway, MRE 11 mutation and Ct. IP expression. Terry J. Gaymes et al. Haematologica 2013; 98: 1397 -1406 © 2013 by Ferrata Storti Foundation