Microcirculation and capillary system ARTERY ARTERIOLES CAPILLARIES VENULES

Interstitial fluid Collagen fibers � Proteoglycan � Fluid � Tissue gel �

Fluid movement through capillary membrane Capillary pressure � Interstitial pressure � Plasma colloid osmotic

Starling equilibrium Under normal condition a state of near equilibrium � exist at the

edema Intracellular edema � ----depression of metabolic system of the tissue � ----lack of

Causes of edema 1. Increase capillary pressure � #. excessive kidney retention of water

causes 2. Decrease plasma proteins. � 3. increase capillary permeability � 4. blockage of

Edema. Heart failure � Kidney disease � Liver disease �

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Microcirculation and capillary system ARTERY ARTERIOLES CAPILLARIES VENULES ENDOTHELIAL CELLS LIPID AND WATER SOLUBLE SUBSTANCES WATER EXCHANGE

Interstitial fluid

Interstitial fluid Collagen fibers � Proteoglycan � Fluid � Tissue gel �

Fluid movement through capillary membrane Capillary pressure � Interstitial pressure � Plasma colloid osmotic pressure � Interstitial fluid colloid osmotic pressure �

Lymphatic system function �

Starling equilibrium Under normal condition a state of near equilibrium � exist at the capillary membrane

edema Intracellular edema � ----depression of metabolic system of the tissue � ----lack of adequate nutrition to the cells � Extracellular edema � ----abnormal leakage of plasma fluid from capillary � to the interstitial fluid ----failure of lymphatic to return fluid back to the � circulation.

Causes of edema 1. Increase capillary pressure � #. excessive kidney retention of water and salt � -mineralocorticoid excess � #. high venous pressure � - heart failure � -venous obstruction � -failure of venous pump � #. decrease arteriolar resistance � Increase body heat, nervous sys abnormalities, drugs �

causes 2. Decrease plasma proteins. � 3. increase capillary permeability � 4. blockage of lymphatic returen �

Edema. Heart failure � Kidney disease � Liver disease �