Micelles as Drug Carriers for Controlled Release Margarita

Micelles as Drug Carriers for Controlled Release Margarita Valero Juan Physical Chemistry Department Pharmacy Faculty Salamanca University ATHENS 2014

SALAMANCA, SPAIN Margarita Valero

SALAMANCA MAIN SQUARE

SALAMANCA CATHEDRAL

PHARMACY FACULTY

Physical Chemistry Department

1. - Colloidal Systems Solutions Dispersed particles (10 -6 m to 10 -9 m) ( m-nm) Macrodispersions Dispersed particles: A: liophilic: are soluble in the dispersant medium: aggregation colloids or polymers B: liophobic: are not soluble in the dispersant medium: -emulsions (liquid/liquid) -suspensions (solid/liquid)

2. - Micelles Formation APOLAR INNER SOLUTION (DISSOLVED) HYDROPHOBIC SURFACE INTERFACE (ADSORBED) HYDROPHYLIC SURFACE

3. - Stucture of Micelles Potential Value: Zeta potenlial (ξ) IONICS - -x -x x - x- - NON IONICS + x+ x+ + Electrical Potential + H 2 O H 2 O + x+ H 2 O x+ + + H 2 O x+ H 2 O H 2 O DIFUSSE LAYER: ”GOUY” FIX LAYER: ”STERN” DOBLE ELECTRIC LAYER : “GOUY CHAPMAN” “PALISADE LAYER”

4. - Properties of Micelles LOADDING + molecules polarity KP KP: Partition KP = [molecule]micelle [molecule]H 2 O

5. - Solubilization and Microemulsions • MICROEMULSIÓN

6. - Other Types of Micelles and Aggregates

6. - Fluorescence Spectroscopy PHOTOPHYSICS PROCESSES l. Fmax lem-labs= Stokes Shift PHOTONS DEACTIVATED F = -------------------ABSORBED PHOTONS * QUENCHIG t: lifetime

BIOLUMINISCENCE

BIOLUMINISCENCE

BIOLUMINISCENCE

Borealis Aurorae