Methanol and Ethanol Analysis The Ultimate Gourmet Martini

Objective n n Analyze methanol and ethanol at 100 -1000 ug/L or lower Use

Warning n n Methanol is “wood alcohol” minimum lethal dose 1 g/kg but toxic

Problems n n Very Poor purging efficiency (i. e. , NO 5030/5035) Allowed Prep.

Problems II n n Low sensitivity on FID and MS Interferences by HCs and

HP Labs’ Solution n n Direct Aqueous injection/EPA Method 8260 B GC Column and

Sample Preparation: water n n n Sample Size 1 m. L Add Labeled IS

Sample Preparation: Soil n n Ultrasonic extraction (EPA 3550) 10 g/10 m. L Remove

Limits n n Detection Water and Soil MDLs < 100 ug/L (ug/kg) EQLs 250

What This Means n n Methanol and Ethanol on site or off site Rapid

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Methanol and Ethanol Analysis/ The Ultimate Gourmet Martini J. Picker HP Labs Escondido, CA

Objective n n Analyze methanol and ethanol at 100 -1000 ug/L or lower Use standard or modified EPA Methods Provide adequate Turnaround and pricing to meet client needs Make a profit HP Labs Escondido, CA

Warning n n Methanol is “wood alcohol” minimum lethal dose 1 g/kg but toxic effects as low as 10 g. toxicity is due to metabolic production of formic acid Ethanol is less toxic HP Labs Escondido, CA

Problems n n Very Poor purging efficiency (i. e. , NO 5030/5035) Allowed Prep. Techniques 5031 Azeotropic distillation u 5032 Vacuum distillation u 5021 Equilibrium Headspace =nd u 5041 VOST train = nd u Direct Inject u HP Labs Escondido, CA

Problems II n n Low sensitivity on FID and MS Interferences by HCs and other compounds on FID HP Labs Escondido, CA

HP Labs’ Solution n n Direct Aqueous injection/EPA Method 8260 B GC Column and conditions to separate Me. OH, Et. OH from water Stable Labeled isotope internal standards (CD 3 OH, CD 3 CH 2 OH) Modified with Selected Ion Monitoring Mass Spectrometry (SIM) HP Labs Escondido, CA

HP Labs Escondido, CA