Metformin alters the insulin signaling pathway in ischemic Slides: 5 Download presentation Metformin alters the insulin signaling pathway in ischemic cardiac tissue in a swine model of metabolic syndrome Nassrene Y. Elmadhun, MD, Antonio D. Lassaletta, MD, Louis M. Chu, MD, Frank W. Sellke, MD The Journal of Thoracic and Cardiovascular Surgery Volume 145 Issue 1 Pages 258 -266 (January 2013) DOI: 10. 1016/j. jtcvs. 2012. 09. 028 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions Figure 1 The Journal of Thoracic and Cardiovascular Surgery 2013 145258 -266 DOI: (10. 1016/j. jtcvs. 2012. 09. 028) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions Figure 2 The Journal of Thoracic and Cardiovascular Surgery 2013 145258 -266 DOI: (10. 1016/j. jtcvs. 2012. 09. 028) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions Figure 3 The Journal of Thoracic and Cardiovascular Surgery 2013 145258 -266 DOI: (10. 1016/j. jtcvs. 2012. 09. 028) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions Figure 4 The Journal of Thoracic and Cardiovascular Surgery 2013 145258 -266 DOI: (10. 1016/j. jtcvs. 2012. 09. 028) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions Insulin and insulin receptorSynthesis of insulinAtrailTenecteplase ischemic strokeHemorrhagic vs ischemic stroke symptomsPathophysiology of ischemic heart disease